Constitutional Thinness: tALKing the tALK or wALKing the wALK?

Y C Loraine Tung; Stephen O'Rahilly

doi:10.1016/j.cmet.2020.06.012

Constitutional Thinness: tALKing the tALK or wALKing the wALK?

Cell Metab. 2020 Jul 7;32(1):8-10. doi: 10.1016/j.cmet.2020.06.012.

Authors

Y C Loraine Tung¹, Stephen O'Rahilly²

Affiliations

¹ MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Cambridge, UK.
² MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Cambridge, UK; Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK; Cambridge NIHR Biomedical Research Centre, Cambridge, UK; Addenbrooke's Hospital, Cambridge, UK. Electronic address: [email protected].

PMID: 32640247
DOI: 10.1016/j.cmet.2020.06.012

Abstract

In a recent issue of Cell, Orthofer et al. (2020) present a body of data from mice, flies, and humans that suggest (1) a physiological role for Alk in the normal control of energy balance across several species and (2) a possible contribution of genetic variants in or near ALK to the variability of adiposity in humans, more specifically at its lower end.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Energy Metabolism
Mice
Obesity*
Receptor Protein-Tyrosine Kinases
Thinness*

Substances

Receptor Protein-Tyrosine Kinases

Abstract

Publication types

MeSH terms

Substances

Grants and funding