Molecular characterization of ataxia telangiectasia T cell clones. III. Mapping the 14q32.1 distal breakpoint

M H Stern; F R Zhang; G Thomas; C Griscelli; A Aurias

doi:10.1007/BF00283722

Molecular characterization of ataxia telangiectasia T cell clones. III. Mapping the 14q32.1 distal breakpoint

Hum Genet. 1988 Dec;81(1):18-22. doi: 10.1007/BF00283722.

Authors

M H Stern¹, F R Zhang, G Thomas, C Griscelli, A Aurias

Affiliation

¹ INSERM U. 132, Hôpital Necker, Paris, France.

PMID: 3264259
DOI: 10.1007/BF00283722

Abstract

To delimit the 14q32.1 recurrent breakpoint of ataxia telangiectasia clones, we performed an in situ hybridization study with various probes located on the 14q32 band. We thus mapped this breakpoint between the D14S1 and Pi loci. Furthermore, an interstitial duplication including D14S1 and a part of the IgH locus was demonstrated on a t(14;14) clone.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ataxia Telangiectasia / genetics*
Chromosome Aberrations*
Chromosome Banding
Chromosome Mapping*
Chromosomes, Human, Pair 14*
DNA Probes
Humans
Karyotyping
Nucleic Acid Hybridization
T-Lymphocytes

Substances

DNA Probes