Oncoplastic Repair in Breast Conservation: Comprehensive Evaluation of Techniques and Oncologic Outcomes of 937 Patients

Clin Breast Cancer. 2020 Dec;20(6):511-519. doi: 10.1016/j.clbc.2020.05.016. Epub 2020 Jun 7.

Abstract

Background: Breast-conserving surgery, especially with oncoplastic breast surgery (OBS), is becoming the standard of care in the surgical management of breast cancer. We investigated the applied technique of OBS and oncologic outcomes in a large series of patients.

Patients and methods: This study was conducted between January 2008 and June 2018 in two centers in Iran. Patients underwent OBS. Early and late postoperative complications, oncologic outcomes, and follow-up data were documented.

Results: Nine hundred thirty-seven patients with a mean ± standard deviation age of 48.1 ± 11.3 underwent OBS. Most of the patients were diagnosed with early-stage disease, of which the most common pathology was invasive ductal carcinoma (83.3%). Lateral oncoplasty was the most commonly used OBS technique (324 cases, 34.6%). The most common complication was seroma formation. Reduction-type OBS technique had the highest rate of complications (13.1%). Thirty-four patients (5.4%) experienced local recurrence, with a median recurrence time of 26.4 months. Nine patients (1.3%) died from cancer recurrence.

Conclusion: OBS is a safe procedure with minor complications and good oncologic outcomes. These techniques can be applied to most patients who are candidates for breast-conserving surgery.

Keywords: Breast cancer; Breast surgery; Oncoplastic breast surgery; Recurrence; Surgical technique.

MeSH terms

  • Adult
  • Breast / pathology
  • Breast / surgery
  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / mortality
  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy*
  • Chemotherapy, Adjuvant / statistics & numerical data
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Humans
  • Iran / epidemiology
  • Mammaplasty / adverse effects*
  • Mammaplasty / methods
  • Mammaplasty / statistics & numerical data
  • Margins of Excision
  • Mastectomy, Segmental / adverse effects*
  • Mastectomy, Segmental / statistics & numerical data
  • Middle Aged
  • Neoadjuvant Therapy / methods
  • Neoadjuvant Therapy / statistics & numerical data
  • Neoplasm Recurrence, Local / epidemiology*
  • Neoplasm Staging
  • Postoperative Complications / epidemiology*
  • Postoperative Complications / etiology
  • Prospective Studies
  • Reoperation / statistics & numerical data
  • Retrospective Studies