How does COVID-19 fear and anxiety affect chemotherapy adherence in patients with cancer

Future Oncol. 2020 Oct;16(29):2283-2293. doi: 10.2217/fon-2020-0592. Epub 2020 Jul 17.

Abstract

Aim: To investigate how COVID-19 fear and anxiety (COV-FA) affects chemotherapy adherence in patients with cancer. Materials & methods: The records of 3661 patients with chemotherapy (CT) appointments were retrospectively reviewed. Results: The CT postponement rates before and after COVID-19 were 11.6% and 14.2%, respectively (p = 0.017). The rate of COV-FA-related CT postponement after telemedicine was lower than that before (4.6% vs 17.4%; p = 0.012). The median time to come back to treatment of the COV-FA group was 47 days (range 19-72 days). Advanced age (≥60 years) was found to be the independent factor that was predictive of time to come back to treatment (p = 0.043). Conclusion: The CT postponement rate increased after COVID-19. COV-FA-related CT postponement decreased after telemedicine. Advanced age could be predictive of time to come back to treatment.

Keywords: COVID-19; anxiety; cancer; chemotherapy adherence; fear; telemedicine.

MeSH terms

  • Age Factors
  • Aged
  • Antineoplastic Agents / therapeutic use*
  • Anxiety / epidemiology
  • Anxiety / etiology
  • Anxiety / psychology
  • Anxiety / rehabilitation
  • Betacoronavirus / immunology*
  • Betacoronavirus / pathogenicity
  • COVID-19
  • Coronavirus Infections / epidemiology
  • Coronavirus Infections / immunology
  • Coronavirus Infections / psychology*
  • Coronavirus Infections / transmission
  • Fear / psychology
  • Female
  • Humans
  • Infection Control / standards
  • Male
  • Medical Oncology / methods
  • Medical Oncology / organization & administration
  • Medical Oncology / standards
  • Medication Adherence / psychology
  • Medication Adherence / statistics & numerical data*
  • Middle Aged
  • Neoplasms / drug therapy*
  • Neoplasms / immunology
  • Neoplasms / psychology
  • No-Show Patients / psychology
  • No-Show Patients / statistics & numerical data
  • Pandemics
  • Pneumonia, Viral / epidemiology
  • Pneumonia, Viral / immunology
  • Pneumonia, Viral / psychology*
  • Pneumonia, Viral / transmission
  • Psychometrics / statistics & numerical data
  • Retrospective Studies
  • SARS-CoV-2
  • Self Report / statistics & numerical data
  • Telemedicine / methods
  • Telemedicine / organization & administration
  • Telemedicine / standards

Substances

  • Antineoplastic Agents