Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

James E D Thaventhiran; Hana Lango Allen; Oliver S Burren; William Rae; Daniel Greene; Emily Staples; Zinan Zhang; James H R Farmery; Ilenia Simeoni; Elizabeth Rivers; Jesmeen Maimaris; Christopher J Penkett; Jonathan Stephens; Sri V V Deevi; Alba Sanchis-Juan; Nicholas S Gleadall; Moira J Thomas; Ravishankar B Sargur; Pavels Gordins; Helen E Baxendale; Matthew Brown; Paul Tuijnenburg; Austen Worth; Steven Hanson; Rachel J Linger; Matthew S Buckland; Paula J Rayner-Matthews; Kimberly C Gilmour; Crina Samarghitean; Suranjith L Seneviratne; David M Sansom; Andy G Lynch; Karyn Megy; Eva Ellinghaus; David Ellinghaus; Silje F Jorgensen; Tom H Karlsen; Kathleen E Stirrups; Antony J Cutler; Dinakantha S Kumararatne; Anita Chandra; J David M Edgar; Archana Herwadkar; Nichola Cooper; Sofia Grigoriadou; Aarnoud P Huissoon; Sarah Goddard; Stephen Jolles; Catharina Schuetz; Felix Boschann; Primary Immunodeficiency Consortium for the NIHR Bioresource; Paul A Lyons; Matthew E Hurles; Sinisa Savic; Siobhan O Burns; Taco W Kuijpers; Ernest Turro; Willem H Ouwehand; Adrian J Thrasher; Kenneth G C Smith

doi:10.1038/s41586-020-2556-6

Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Nature. 2020 Aug;584(7819):E2. doi: 10.1038/s41586-020-2556-6.

Authors

James E D Thaventhiran^#^{1

2

3}, Hana Lango Allen^#^{4

5

6

7}, Oliver S Burren^#^{8

9}, William Rae^#^{8

9}, Daniel Greene^{4

6

10}, Emily Staples⁹, Zinan Zhang^{8

9

11}, James H R Farmery^{10

12}, Ilenia Simeoni^{4

6}, Elizabeth Rivers^{13

14}, Jesmeen Maimaris^{13

14}, Christopher J Penkett^{4

6}, Jonathan Stephens^{4

5

6}, Sri V V Deevi^{4

6}, Alba Sanchis-Juan^{4

5

6}, Nicholas S Gleadall^{4

5}, Moira J Thomas^{15

16}, Ravishankar B Sargur^{17

18}, Pavels Gordins¹⁹, Helen E Baxendale^{8

9

20}, Matthew Brown^{4

6}, Paul Tuijnenburg^{21

22}, Austen Worth^{13

14}, Steven Hanson^{23

24}, Rachel J Linger^{6

25}, Matthew S Buckland^{23

24}, Paula J Rayner-Matthews^{4

6}, Kimberly C Gilmour^{13

14}, Crina Samarghitean^{4

6}, Suranjith L Seneviratne^{23

24}, David M Sansom^{23

24}, Andy G Lynch^{12

26

27}, Karyn Megy^{4

6}, Eva Ellinghaus²⁸, David Ellinghaus^{29

30}, Silje F Jorgensen^{31

32}, Tom H Karlsen²⁸, Kathleen E Stirrups^{4

6}, Antony J Cutler³³, Dinakantha S Kumararatne^{9

34}, Anita Chandra^{8

9

34}, J David M Edgar^{35

36}, Archana Herwadkar³⁷, Nichola Cooper³⁸, Sofia Grigoriadou³⁹, Aarnoud P Huissoon^{40

41}, Sarah Goddard⁴², Stephen Jolles⁴³, Catharina Schuetz⁴⁴, Felix Boschann⁴⁵; Primary Immunodeficiency Consortium for the NIHR Bioresource; Paul A Lyons^{8

9}, Matthew E Hurles⁴⁶, Sinisa Savic^{47

48

49}, Siobhan O Burns^{23

24}, Taco W Kuijpers^{21

22

50}, Ernest Turro^{4

5

6

10}, Willem H Ouwehand^{4

5

6

51}, Adrian J Thrasher^{13

14}, Kenneth G C Smith^{52

53}

Collaborators

Primary Immunodeficiency Consortium for the NIHR Bioresource:
Stephen Abbs, Zoe Adhya, Julian Adlard, Maryam Afzal, Irshad Ahmed, Munaza Ahmed, Saeed Ahmed, Timothy J Aitman, Hana Alachkar, Jayanthi Alamelu, Raza Alikhan, Carl E Allen, Louise Allen, David J Allsup, Arif Alvi, Gautam Ambegaonkar, Ariharan Anantharachagan, Philip Ancliff, Julie Anderson, Richard Antrobus, Ruth Armstrong, Gavin Arno, Gururaj Arumugakani, Rita Arya, Sofie Ashford, William J Astle, Anthony Attwood, Steve Austin, Yesim Aydinok, Waqar Ayub, Christian Babbs, Chiara Bacchelli, Trevor Baglin, Tamam Bakchoul, Tadbir K Bariana, Jonathan Barratt, Julian Barwell, John Baski, Rachel W Bates, Joana Batista, Helen E Baxendale, Gareth Baynam, David L Bennett, Claire Bethune, Neha Bhatnagar, Shahnaz Bibi, Agnieszka Bierzynska, Tina Biss, Maria A K Bitner-Glindzicz, Marta Bleda, Iulia Blesneac, Barbara Boardman, Preetham Boddana, Harm J Bogaard, Claire Booth, Sara Boyce, John R Bradley, Angela Brady, Gerome Breen, Paul Brennan, Carole Brewer, Annette Briley, Matthew Brown, Richard Brown, Michael J Browning, Mary Brownlie, Christine J Bryson, Rachel J Buchan, Jackie Buck, Matthew S Buckland, Teofila Bueser, Carmen Bugarin Diz, Siobhan O Burns, Oliver S Burren, Paul Calleja, Jenny Carmichael, Gerald Carr-White, Keren J Carss, Ruth Casey, Elizabeth Chalmers, Jenny Chambers, John Chambers, Melanie M Y Chan, Melissa V Chan, Anita Chandra, Floria Cheng, Ivan K Chinn, Patrick F Chinnery, Manali Chitre, Sam Chong, Martin T Christian, Colin Church, Emma M Clement, Naomi Clements Brod, Hayley Clifford, Virginia E Clowes, Gerry Coghlan, Elizabeth Colby, Trevor R P Cole, Janine H Collins, Peter W Collins, Robin Condliffe, H Terence Cook, Stuart Cook, Victoria Cookson, Nichola Cooper, Paul A Corris, Amanda Creaser-Myers, Abigail Crisp-Hihn, Nicola S Curry, Antony J Cutler, Rosa Da Costa, Cesare Danesino, Matthew J Daniels, Damaris Darby, Louise C Daugherty, E G Davies, Sophie Davies, John Davis, Godelieve J de Bree, Sarah Deacock, Patrick B Deegan, Sri V V Deevi, John Dempster, Timothy Dent, Charu Deshpande, Lisa A Devlin, Eleanor F Dewhurst, Anand K Dixit, Peter H Dixon, Rainer Doffinger, Helen Dolling, Natalie Dormand, Kate Downes, Anna M Drazyk, Elizabeth Drewe, Daniel Duarte, Tina Dutt, J David M Edgar, Karen E Edwards, William Egner, Melanie N Ekani, Tariq El-Shanawany, Shuayb Elkhalifa, Tony Elston, Ingrid Emmerson, Wendy N Erber, Marie Erwood, Maria C Estiu, Dafydd Gareth Evans, Gillian Evans, Tamara Everington, Mélanie Eyries, James H R Farmery, Remi Favier, Helen V Firth, Maggie M Fitzpatrick, Debra Fletcher, Frances A Flinter, James C Fox, Amy J Frary, Courtney E French, Kathleen Freson, Mattia Frontini, Bruce Furie, Daniel P Gale, Henning J Gall, Alice Gardham, H Bobby Gaspar, Michael Gattens, Neeti Ghali, Pavandeep K Ghataorhe, Stefano Ghio, Hossein-Ardeschir Ghofrani, Rohit Ghurye, J Simon R Gibbs, Rodney D Gilbert, Kimberly C Gilmour, Barbara Girerd, Joanna C Girling, Paul Gissen, Nicholas S Gleadall, Sarah Goddard, Pavels Gordins, Kathleen M Gorman, David Gosal, Stefan Graf, Luigi Grassi, Daniel Greene, Alan J Greenhalgh, Lynn Greenhalgh, Andreas Greinacher, Paolo Gresele, Philip G Griffiths, Sian Griffiths, Sofia Grigoriadou, Detelina Grozeva, Scott J Hackett, Robert D M Hadden, Charaka Hadinnapola, Rosie Hague, William M Hague, Matthias Haimel, Matthew Hall, Csaba Halmagyi, Tracey Hammerton, Helen L Hanson, Kirsty Harkness, Andrew R Harper, Lorraine Harper, Claire Harris, Claire Harrison, Daniel Hart, Ahamad Hassan, Grant Hayman, Johan W M Heemskerk, Shivaram Hegde, Alex Henderson, Robert H Henderson, Anke Hensiek, Yvonne M C Henskens, Archana Herwadkar, Joshua Hodgson, Jonathan Hoffman, Simon Holden, Muriel Holder, Rita Horvath, Henry Houlden, Arjan C Houweling, Luke S Howard, Fengyuan Hu, Gavin Hudson, Sean Hughes, Stephen Hughes, Anna E Huis In 't Veld, Aarnoud P Huissoon, Marc Humbert, Matthew E Hurles, Jane A Hurst, Val Irvine, Louise Izatt, Roger James, Praveen Jeevaratnam, Mark Johnson, Sally A Johnson, Stephen Jolles, Jennifer D Jolley, Bryony Jones, Julie Jones, Dragana Josifova, Neringa Jurkute, Yousuf M Karim, Mahantesh A Karoshi, Mary A Kasanicki, Hanadi Kazkaz, Rashid Kazmi, David Keeling, Peter Kelleher, Anne M Kelly, Carly Kempster, Fiona Kennedy, Sorena Kiani, David G Kiely, Nathalie Kingston, Sally Kinsey, Nigel Klein, Robert Klima, Ellen Knox, Myrto A Kostadima, Gabor Kovacs, Ania B Koziell, Roman Kreuzhuber, Deepa Krishnakumar, Taco W Kuijpers, Ajith Kumar, Dinakantha S Kumararatne, Manju A Kurian, James Laffan, Michael A Laffan, Fiona Lalloo, Michele P Lambert, Hana Lango Allen, Sarah H A Lawman, Allan Lawrie, D Mark Layton, Sara E Lear, Melissa M Lees, Claire Lentaigne, Adam P Levine, Andrew J P Lewington, Wei Li, Ri Liesner, Rachel J Linger, Bin Liu, Hilary Longhurst, Lorena E Lorenzo, Eleni Louka, Silvia Lucato Hadeler, Paul A Lyons, Malcolm Macdougall, Rajiv D Machado, Robert V MacKenzie Ross, Lucy H Mackillop, Robert MacLaren, Bella Madan, Laura Magee, Mohamed Mahdi-Rogers, Eamonn R Maher, Jesmeen Maimaris, Mike Makris, Sarah Mangles, Ania Manson, Adnan Manzur, Rutendo Mapeta, Kevin J Marchbank, Patrick B Mark, Stephen Marks, Hugh S Markus, Hanns-Ulrich Marschall, Andrew Marshall, Jennifer M Martin, Larahmie Masati, Mary Mathias, Vera Matser, Emma L Matthews, Anna Maw, Heather Maxwell, Paul McAlinden, Mark I McCarthy, Elizabeth M McDermott, Simon J McGowan, Coleen McJannet, Harriet McKinney, Stuart Meacham, Adam J Mead, Ignacio Medina Castello, Sharon Meehan, Karyn Megy, Sarju Mehta, Catherine L Mercer, Michel Michaelides, Anna C Michell, David Milford, Carolyn M Millar, Hazel Millar, Anoop Mistry, Floor Moenen, Shahin Moledina, David Montani, Anthony T Moore, Jason Moore, Nicholas W Morrell, Valerie Morrisson, Monika Mozere, Keith W Muir, Andrew D Mumford, Sai H K Murng, Iman Nasir, Sergey Nejentsev, Michael Newnham, Joanne Ng, Adeline Ngoh, Sadia Noorani, Muna Noori, Paquita Nurden, Jennifer M O'Sullivan, Samya Obaji, Steven Okoli, Eric Oksenhendler, Andrea Olschewski, Horst Olschewski, Albert C M Ong, Kai Ren Ong, Helen Oram, Elizabeth Ormondroyd, Shokri Othman, Willem H Ouwehand, Antonis Pantazis, Sofia Papadia, Apostolos Papandreou, Soo-Mi Park, Alasdair P J Parker, David Parry, Georgina Parsons, K John Pasi, Joan Paterson, Jeanette H Payne, Andrew J Peacock, Kathelijne Peerlinck, Christopher J Penkett, Joanna Pepke-Zaba, David Perry, Romina Petersen, Bartlomiej Piechowski-Jozwiak, Fernando Pinto, Gary J Polwarth, Mark J Ponsford, Sanjay Prasad, Inga Prokopenko, Beth Psaila, Angela Pyle, Waseem Qasim, Ellen Quinn, Isabella Quinti, Sanjay Raina, Lavanya Ranganathan, Julia Rankin, Stuart Rankin, Anupama Rao, F Lucy Raymond, Paula J Rayner-Matthews, Karola Rehnstrom, Evan Reid, Mary M Reilly, Tara Renton, Shoshana Revel-Vilk, Christopher J Rhodes, Andrew S C Rice, Emma E Richards, Mike Richards, Sylvia Richardson, Alex Richter, Leema Robert, Irene Roberts, Matthew T Rondina, Elisabeth Rosser, Peter Rothwell, Catherine Roughley, Noemi B Roy, Kevin Rue-Albrecht, Omid Sadeghi-Alavijeh, Moin A Saleem, Richard M Salmon, Nilesh J Samani, Crina Samarghitean, Jennifer G Sambrook, Alba Sanchis-Juan, Richard Sandford, Saikat Santra, Ravishankar B Sargur, Simon C Satchell, Sinisa Savic, Laura Scelsi, Gwen Schotte, Sol Schulman, Harald Schulze, Richard Scott, Marie Scully, Claire Searle, Werner Seeger, Suranjith L Seneviratne, W A Carrock Sewell, Denis Seyres, Fiona Shackley, Olga Shamardina, Susan E Shapiro, Pankaj Sharma, Hassan A Shehata, Deborah Shipley, Rakefet Shtoyerman, Keith Sibson, Lucy Side, Ilenia Simeoni, Michael Simpson, Matthew C Sims, Manish D Sinha, Suthesh Sivapalaratnam, Anne-Bine Skytte, Kenneth G C Smith, Katie Snape, Linda Sneddon, Aman Sohal, Florent Soubrier, Laura Southgate, Mark Southwood, Miranda Splitt, Simon Staines, Emily Staples, Hannah Stark, Hans Stauss, Cathal L Steele, Daniel Stein, Penelope E Stein, Jonathan Stephens, Kathleen E Stirrups, Sophie Stock, Matthew J Stubbs, Jay Suntharalingam, Emilia M Swietlik, Emily Symington, R Campbell Tait, Kate Talks, Rhea Y Y Tan, Gordon B Taylor, Jecko Thachil, James E D Thaventhiran, Andreas C Themistocleous, David C Thomas, Ellen Thomas, Moira J Thomas, Patrick Thomas, Dorothy A Thompson, Kate Thomson, Adrian J Thrasher, Chantal Thys, Tobias Tilly, Marc Tischkowitz, Catherine Titterton, John A Todd, Cheng-Hock Toh, Anton T J Tool, Mark R Toshner, Matthew Traylor, Carmen M Treacy, Paul Treadaway, Richard C Trembath, Sarah Trippier, Salih Tuna, Wojciech Turek, Ernest Turro, Paul D Upton, Rafal Urniaz, Tom Vale, Chris Van Geet, Natalie van Zuydam, Anthony M Vandersteen, Marta Vazquez-Lopez, Marijcke W M Veltman, Julie Vogt, Julie von Ziegenweidt, Anton Vonk Noordegraaf, Ajay Vora, Minka J A Vries, Emma L Wakeling, Neil Walker, Suellen M Walker, Roddy Walsh, Ivy Wanjiku, James S Ware, Timothy Q Warner, Evangeline Wassmer, Hugh Watkins, Henry G Watson, Christopher Watt, Dean Waugh, Nick Webb, Andrew R Webster, Wei Wei, Angela Welch, Steven B Welch, David Werring, Julie Wessels, Sarah K Westbury, John-Paul W Westwood, John Wharton, Deborah Whitehorn, James Whitworth, Martin R Wilkins, Lisa Willcocks, David J Williams, Catherine Williamson, Edwin K S Wong, Nicholas Wood, Yvette Wood, Christopher Geoffrey Woods, Emma R Woodward, Sarita Workman, Stephen J Wort, Austen Worth, Katherine Yates, Nigel Yeatman, Patrick F K Yong, Timothy Young, Ping Yu, Patrick Yu-Wai-Man, Eliska Zlamalova

Affiliations

¹ Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK. [email protected].
² Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK. [email protected].
³ Medical Research Council Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge, UK. [email protected].
⁴ Department of Haematology, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
⁵ NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK.
⁶ NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, UK.
⁷ Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
⁸ Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.
⁹ Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
¹⁰ Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Cambridge, UK.
¹¹ Molecular Development of the Immune System Section, Laboratory of Immune System Biology and Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
¹² Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.
¹³ UCL Great Ormond Street Institute of Child Health, London, UK.
¹⁴ Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
¹⁵ Department of Immunology, Queen Elizabeth University Hospital, Glasgow, UK.
¹⁶ Gartnavel General Hospital, NHS Greater Glasgow and Clyde, Glasgow, UK.
¹⁷ Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
¹⁸ Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.
¹⁹ East Yorkshire Regional Adult Immunology and Allergy Unit, Hull Royal Infirmary, Hull and East Yorkshire Hospitals NHS Trust, Hull, UK.
²⁰ Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.
²¹ Department of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Amsterdam, The Netherlands.
²² Department of Experimental Immunology, Amsterdam University Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands.
²³ Institute of Immunity and Transplantation, University College London, London, UK.
²⁴ Department of Immunology, Royal Free London NHS Foundation Trust, London, UK.
²⁵ Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
²⁶ School of Mathematics and Statistics, University of St Andrews, St Andrews, UK.
²⁷ School of Medicine, University of St Andrews, St Andrews, UK.
²⁸ K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway.
²⁹ Department of Transplantation, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway.
³⁰ Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
³¹ Section of Clinical Immunology and Infectious Diseases, Department of Rheumatology, Dermatology and Infectious Diseases, Oslo University Hospital, Oslo, Norway.
³² Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Oslo, Norway.
³³ JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
³⁴ Department of Clinical Biochemistry and Immunology, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, UK.
³⁵ St James's Hospital, Dublin, Ireland.
³⁶ Trinity College Dublin, Dublin, Ireland.
³⁷ Salford Royal NHS Foundation Trust, Salford, UK.
³⁸ Department of Medicine, Imperial College London, London, UK.
³⁹ Barts Health NHS Foundation Trust, London, UK.
⁴⁰ West Midlands Immunodeficiency Centre, University Hospitals Birmingham, Birmingham, UK.
⁴¹ Birmingham Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
⁴² University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK.
⁴³ Immunodeficiency Centre for Wales, University Hospital of Wales, Cardiff, UK.
⁴⁴ Department of Pediatric Immunology, University Hospital Carl Gustav Carus, Dresden, Germany.
⁴⁵ Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
⁴⁶ Department of Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
⁴⁷ Department of Clinical Immunology and Allergy, St James's University Hospital, Leeds, UK.
⁴⁸ The NIHR Leeds Biomedical Research Centre, Leeds, UK.
⁴⁹ Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, UK.
⁵⁰ Department of Blood Cell Research, Sanquin, Amsterdam, The Netherlands.
⁵¹ Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
⁵² Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK. [email protected].
⁵³ Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK. [email protected].

^# Contributed equally.

PMID: 32678341
DOI: 10.1038/s41586-020-2556-6

Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Published Erratum

Abstract

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