The cutaneous and intestinal microbiome in psoriatic disease

Stephanie T Le; Atrin Toussi; Natalia Maverakis; Alina I Marusina; Virgina R Barton; Alexander A Merleev; Guillaume Luxardi; Siba P Raychaudhuri; Emanual Maverakis

doi:10.1016/j.clim.2020.108537

The cutaneous and intestinal microbiome in psoriatic disease

Clin Immunol. 2020 Sep:218:108537. doi: 10.1016/j.clim.2020.108537. Epub 2020 Jul 15.

Authors

Stephanie T Le¹, Atrin Toussi², Natalia Maverakis³, Alina I Marusina¹, Virgina R Barton¹, Alexander A Merleev¹, Guillaume Luxardi¹, Siba P Raychaudhuri⁴, Emanual Maverakis⁵

Affiliations

¹ Department of Dermatology, University of California, Davis, Sacramento, CA, United States.
² Department of Dermatology, University of California, Davis, Sacramento, CA, United States; University of California, Davis, School of Medicine, Sacramento, CA, United States.
³ New York University, New York City, NY, United States.
⁴ Department of Dermatology, University of California, Davis, Sacramento, CA, United States; Department of Medicine, VA Medical Center, Mather, CA, USA; Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, Sacramento, CA, United States.
⁵ Department of Dermatology, University of California, Davis, Sacramento, CA, United States. Electronic address: [email protected].

PMID: 32679247
DOI: 10.1016/j.clim.2020.108537

Abstract

Psoriasis (PsO) and psoriatic arthritis (PsA) are chronic immune-mediated inflammatory diseases of multifactorial etiology. In addition to genetic and environmental factors, evidence supports involvement of a dysregulated human microbiome in the pathogenesis of psoriatic disease. In particular, alterations in the composition of the microbiome, termed dysbiosis, can result in downstream proinflammatory effects in the gut, skin, and joints. Both the cutaneous and intestinal microbial populations are implicated in the pathogenesis of psoriatic disease, although exact mechanisms are unclear. Herein, we review the relationship between the human microbiome and psoriatic disease. Further insight into the functions of the microbiome may allow for greater understanding of inflammatory disease processes and identification of additional therapeutic targets.

Keywords: Autoimmunity; Inflammatory bowel disease; Microbiome; Psoriasis; Psoriatic arthritis.

Publication types

Review

MeSH terms

Animals
Gastrointestinal Tract / microbiology*
Humans
Microbiota*
Psoriasis / microbiology*
Skin / microbiology*