Shed it, and help-LAG3 cleavage drives conventional CD4+ T cells to overcome resistance to PD-1 immunotherapy

Shed it, and help-LAG3 cleavage drives conventional CD4⁺ T cells to overcome resistance to PD-1 immunotherapy

Sci Immunol. 2020 Jul 17;5(49):eabc8644. doi: 10.1126/sciimmunol.abc8644.

Lea Seidel^{1

2

3

4}, Bertram Bengsch^{5

2}

¹ Faculty of Medicine, Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.
² Signaling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.
³ SGBM - Spemann Graduate School of Biology and Medicine, University of Freiburg, Freiburg, Germany.
⁴ Faculty of Biology, University of Freiburg, Freiburg, Germany.
⁵ Faculty of Medicine, Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany. [email protected].

LAG3 cleavage from conventional CD4⁺ T cells, but not CD8⁺ T cells, is required for effective PD-1 blockade.