YB-1: The key to personalised prostate cancer management?

Cancer Lett. 2020 Oct 10:490:66-75. doi: 10.1016/j.canlet.2020.07.006. Epub 2020 Jul 16.

Abstract

Y-box-binding protein 1 (YB-1) is a DNA/RNA binding protein increasingly implicated in the regulation of cancer cell biology. Normally located in the cytoplasm, nuclear localisation in prostate cancer is associated with more aggressive, potentially treatment-resistant disease. This is attributed to the ability of YB-1 to act as a transcription factor for various target genes associated with androgen receptor signalling, survival, DNA repair, proliferation, invasion, differentiation, angiogenesis and hypoxia. This review aims to examine the clinical potential of YB-1 in the detection and therapeutic management of prostate cancer.

Keywords: Prognostic biomarkers; Prostate cancer; Radiation therapy; Treatment resistance; Y-box-binding protein 1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers, Tumor*
  • Humans
  • Male
  • Precision Medicine
  • Prostatic Neoplasms, Castration-Resistant / genetics
  • Prostatic Neoplasms, Castration-Resistant / metabolism*
  • Prostatic Neoplasms, Castration-Resistant / pathology*
  • Y-Box-Binding Protein 1*

Substances

  • Biomarkers, Tumor
  • Y-Box-Binding Protein 1
  • YBX1 protein, human