Impact of pandemic COVID-19 outbreak on oral mucositis preventive and treatment protocols: new perspectives for extraoral photobiomodulation therapy

Karina Morais Faria; Wagner Gomes-Silva; Elisa Kauark-Fontes; Carolina Guimarães Bonfim-Alves; Luiz Paulo Kowalski; Ana Carolina Prado-Ribeiro; Aljomar José Vechiato-Filho; Marcio Ajudarte Lopes; Gustavo Nader Marta; Gilberto de Castro Jr; Adriana Franco Paes Leme; Cesar Augusto Migliorati; Alan Roger Santos-Silva; Thaís Bianca Brandão

doi:10.1007/s00520-020-05636-1

Impact of pandemic COVID-19 outbreak on oral mucositis preventive and treatment protocols: new perspectives for extraoral photobiomodulation therapy

Support Care Cancer. 2020 Oct;28(10):4545-4548. doi: 10.1007/s00520-020-05636-1. Epub 2020 Jul 21.

Authors

Karina Morais Faria¹, Wagner Gomes-Silva^{1

2}, Elisa Kauark-Fontes³, Carolina Guimarães Bonfim-Alves^{1

3}, Luiz Paulo Kowalski⁴, Ana Carolina Prado-Ribeiro^{1

3}, Aljomar José Vechiato-Filho¹, Marcio Ajudarte Lopes³, Gustavo Nader Marta^{5

6}, Gilberto de Castro Jr⁷, Adriana Franco Paes Leme⁸, Cesar Augusto Migliorati⁹, Alan Roger Santos-Silva¹⁰, Thaís Bianca Brandão¹

Affiliations

¹ Dental Oncology Service, Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, Brazil.
² Medical School, Nove de Julho University, UNINOVE, São Paulo, Brazil.
³ Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.
⁴ Head and Neck Surgery Department, University of Sao Paulo Medical School and Department of Head and Neck Surgery and Otorhinolaryngology A C Camargo Cancer Center, São Paulo, Brazil.
⁵ Division of Radiation Oncology, Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, Brazil.
⁶ Department of Radiation Oncology, Hospital Sírio-Libanês, São Paulo, Brazil.
⁷ Department of Medical Oncology, Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, Brazil.
⁸ Brazilian Biosciences National Laboratory, LNBio, CNPEM, Campinas, São Paulo, Brazil.
⁹ College of Dentistry, University of Florida, Gainesville, Florida, USA.
¹⁰ Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil. [email protected].

Abstract

This communication discusses the current challenges of oral mucositis (OM) management during the pandemic COVID-19 outbreak and reflects about an extraoral photobiomodulation protocol as an optimal alternative for preventing and treating OM in advanced cancer patients while minimizing the risk of infection by avoiding intraoral manipulation.

Keywords: COVID-19; Cancer; Laser therapy; Oral mucositis; Photobiomodulation therapy.

MeSH terms

Antineoplastic Agents / adverse effects*
Antineoplastic Agents / therapeutic use
Betacoronavirus*
COVID-19
Clinical Protocols
Coronavirus Infections* / epidemiology
Disease Outbreaks
Humans
Low-Level Light Therapy*
Neoplasms / drug therapy*
Pandemics*
Pneumonia, Viral* / epidemiology
SARS-CoV-2
Stomatitis / chemically induced
Stomatitis / prevention & control*

Substances

Antineoplastic Agents

Grants and funding

18/02233-6/Fundação de Amparo à Pesquisa do Estado de São Paulo