This is a report of a successful bone marrow transplant in an IFN-γR1 patient with progressive mycobacterial infection.
Purpose: Hematopoietic cell transplant in patients with interferon gamma receptor deficiencies has been fraught with challenges, not the least of which is failure of engraftment and infectious complications.
Methods: This is a report of a successful hematopoietic cell transplant in an actively infected patient of advanced age.
Results: This case report shows successful engraftment and resolution of infection posttransplant using a matched related donor in a single institution.
Conclusion: A successful curative HCT despite persistent, disseminated, nontuberculous mycobacterial infection in a patient with AD-IFNγR1 suggests that this approach, while difficult, may be useful in other patients with otherwise refractory disease.
Keywords: Interferon gamma receptor; hematopoietic cell transplant; infection; nontuberculous mycobacteria.