High glucose distinctively regulates Ca2+ influx in cytotoxic T lymphocytes upon target recognition and thapsigargin stimulation

Huajiao Zou; Wenjuan Yang; Gertrud Schwär; Renping Zhao; Dalia Alansary; Deling Yin; Eva C Schwarz; Barbara A Niemeyer; Bin Qu

doi:10.1002/eji.202048577

High glucose distinctively regulates Ca²⁺ influx in cytotoxic T lymphocytes upon target recognition and thapsigargin stimulation

Eur J Immunol. 2020 Dec;50(12):2095-2098. doi: 10.1002/eji.202048577. Epub 2020 Aug 18.

Authors

Huajiao Zou^{1

2}, Wenjuan Yang², Gertrud Schwär², Renping Zhao², Dalia Alansary³, Deling Yin^{1

4}, Eva C Schwarz², Barbara A Niemeyer³, Bin Qu^{2

5}

Affiliations

¹ Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
² Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.
³ Molecular Biophysics, CIPMM, School of Medicine, Saarland University, Homburg, Germany.
⁴ Department of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, TN, USA.
⁵ INM-Leibniz Institute for New Materials, Saarbrücken, Germany.

PMID: 32697355
DOI: 10.1002/eji.202048577

Abstract

In CTLs: High glucose-culture enhances thapsigargin-induced SOCE but decreases target recognition-induced Ca²⁺ influx. High glucose-culture regulates expression of ORAIs and STIMs without affecting glucose uptake. More high glucose-cultured CTLs are prone to necrosis after execution of killing.

Keywords: SOCE; calcium; cytotoxic T cells; glucose; metabolism.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Calcium / metabolism*
Calcium Channels / metabolism*
Glucose / metabolism*
Humans
Signal Transduction / drug effects
T-Lymphocytes, Cytotoxic / drug effects
T-Lymphocytes, Cytotoxic / metabolism*
Thapsigargin / pharmacology*

Substances

Calcium Channels
Thapsigargin
Glucose
Calcium

Abstract

Publication types

MeSH terms

Substances

Grants and funding