Quantitative Dynamic Contrast-Enhanced MRI Identifies Radiation-Induced Vascular Damage in Patients With Advanced Osteoradionecrosis: Results of a Prospective Study

Int J Radiat Oncol Biol Phys. 2020 Dec 1;108(5):1319-1328. doi: 10.1016/j.ijrobp.2020.07.029. Epub 2020 Jul 23.

Abstract

Purpose: We aim to characterize the quantitative dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters associated with advanced mandibular osteoradionecrosis (ORN) compared with the contralateral normal mandible.

Methods and materials: Patients with a diagnosis of advanced ORN after curative-intent radiation treatment of head and neck cancer were prospectively enrolled after institutional review board approval and study-specific informed consent were obtained. Quantitative maps generated with the Tofts and extended Tofts pharmacokinetic models were used for analysis. Manual segmentation of advanced ORN 3-dimensional volume was done using anatomic sequences to create ORN volumes of interest (VOIs). Subsequently, normal mandibular VOIs were segmented on the contralateral healthy mandible of similar volume and anatomic location to create control VOIs. Finally, anatomic sequences were coregistered to DCE sequences, and contours were propagated to the respective parameter maps.

Results: Thirty patients were included. The median time to ORN diagnosis after completion of IMRT was 38 months (range, 6-184 months), whereas median time to ORN progression to advanced grade after initial diagnosis was 5.6 months (range, 0-128 months). There were statistically significant higher Ktrans and Ve in ORN-VOIs compared with controls (0.23 vs 0.07 min-1, and 0.34 vs 0.15; P < .0001 for both). The average relative increase of Ktrans in ORN-VOIs was 3.2-fold higher than healthy mandibular control VOIs. Moreover, the corresponding rise of Ve in ORN-VOIs was 2.7-fold higher than in the controls. Using combined Ktrans and Ve parameters, 27 patients (90%) had at least a 200% increase of either of the studied parameters in the ORN-VOIs compared with their healthy mandible VOIs.

Conclusions: Our results confirm that there is a quantitatively significant higher degree of leakiness in the mandibular vasculature as measured using DCE-MRI parameters of areas with advanced ORN versus healthy mandible.

Publication types

  • Observational Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Blood Vessels / radiation effects
  • Contrast Media*
  • Dose Fractionation, Radiation
  • Female
  • Head and Neck Neoplasms / blood supply
  • Head and Neck Neoplasms / radiotherapy
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Male
  • Mandible / blood supply
  • Mandible / diagnostic imaging*
  • Mandibular Diseases / diagnostic imaging*
  • Mandibular Diseases / pathology
  • Middle Aged
  • Osteoradionecrosis / diagnostic imaging*
  • Osteoradionecrosis / pathology
  • Prospective Studies
  • Radiation Injuries
  • Radiotherapy, Intensity-Modulated / adverse effects
  • Squamous Cell Carcinoma of Head and Neck / blood supply
  • Squamous Cell Carcinoma of Head and Neck / radiotherapy
  • Statistics, Nonparametric
  • Time Factors
  • Young Adult

Substances

  • Contrast Media