Three Alu repeated sequences associated with a human glandular kallikrein gene

Clin Exp Pharmacol Physiol. 1988 Apr;15(4):339-44. doi: 10.1111/j.1440-1681.1988.tb01084.x.

Abstract

1. Recently the complete primary structure of a human glandular kallikrein gene, hGK-1, was reported. The present paper presents further structural information. 2. Associated with the gene were three Alu repeated sequences; one in the second intron and two approximately 0.4 kb and 1.2 kb upstream. 3. The 5' non-coding and 5' flanking DNA was highly homologous to that in the mouse genes. 4. Different polyadenylation signals are used in different human kallikrein genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Humans
  • Kallikreins / genetics*
  • Mice
  • Molecular Sequence Data
  • Poly A / genetics
  • Protein Sorting Signals
  • Repetitive Sequences, Nucleic Acid*
  • Restriction Mapping
  • Sequence Homology, Nucleic Acid
  • Species Specificity

Substances

  • Protein Sorting Signals
  • Poly A
  • Kallikreins