SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70

Cell Mol Immunol. 2020 Sep;17(9):998-1000. doi: 10.1038/s41423-020-0514-8. Epub 2020 Jul 29.

Authors

He-Wei Jiang^#¹, Hai-Nan Zhang^#¹, Qing-Feng Meng^#¹, Jia Xie^#¹, Yang Li¹, Hong Chen¹, Yun-Xiao Zheng¹, Xue-Ning Wang¹, Huan Qi¹, Jing Zhang², Pei-Hui Wang², Ze-Guang Han¹, Sheng-Ce Tao³

Affiliations

¹ Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, 200240, Shanghai, China.
² Advanced Medical Research Institute, Shandong University, Jinan, 250012, Shandong, China.
³ Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, 200240, Shanghai, China. [email protected].

^# Contributed equally.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Betacoronavirus / genetics*
Betacoronavirus / metabolism
Betacoronavirus / pathogenicity
Gene Expression Regulation
HEK293 Cells
Host-Pathogen Interactions / genetics*
Host-Pathogen Interactions / immunology
Humans
Interferon-beta / genetics*
Interferon-beta / immunology
Mitochondria / metabolism
Mitochondria / virology
Mitochondrial Membrane Transport Proteins / genetics*
Mitochondrial Membrane Transport Proteins / immunology
Mitochondrial Precursor Protein Import Complex Proteins
Open Reading Frames
Promoter Regions, Genetic
Protein Binding
SARS-CoV-2
Sequence Alignment
Sequence Homology, Amino Acid
Severe acute respiratory syndrome-related coronavirus / genetics
Severe acute respiratory syndrome-related coronavirus / metabolism
Severe acute respiratory syndrome-related coronavirus / pathogenicity
Signal Transduction
Viral Proteins / genetics*
Viral Proteins / metabolism

Substances

Mitochondrial Membrane Transport Proteins
Mitochondrial Precursor Protein Import Complex Proteins
TOMM70 protein, human
Viral Proteins
Interferon-beta

Grants and funding