Fusion of the CRM1 nuclear export receptor to AF10 causes leukemia and transcriptional activation of HOXA genes

Leukemia. 2021 Mar;35(3):876-880. doi: 10.1038/s41375-020-0998-3. Epub 2020 Jul 30.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Active Transport, Cell Nucleus
  • Animals
  • Apoptosis
  • Cell Proliferation
  • Cells, Cultured
  • Exportin 1 Protein
  • Gene Expression Regulation, Leukemic
  • Hematopoietic Stem Cells / metabolism
  • Hematopoietic Stem Cells / pathology*
  • Homeodomain Proteins / genetics*
  • Homeodomain Proteins / metabolism
  • Karyopherins / genetics
  • Karyopherins / metabolism*
  • Leukemia, Experimental / etiology
  • Leukemia, Experimental / metabolism
  • Leukemia, Experimental / pathology*
  • Mice
  • Oncogene Proteins, Fusion / genetics
  • Oncogene Proteins, Fusion / metabolism*
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Transcriptional Activation*

Substances

  • Homeodomain Proteins
  • Karyopherins
  • Mllt10 protein, mouse
  • Oncogene Proteins, Fusion
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • HoxA protein