Non-invasive prenatal testing in the context of IVF and PGT-A

Dana Kimelman; Mary Ellen Pavone

doi:10.1016/j.bpobgyn.2020.07.004

Non-invasive prenatal testing in the context of IVF and PGT-A

Best Pract Res Clin Obstet Gynaecol. 2021 Jan:70:51-62. doi: 10.1016/j.bpobgyn.2020.07.004. Epub 2020 Jul 15.

Authors

Dana Kimelman¹, Mary Ellen Pavone²

Affiliations

¹ Centro de Esterilidad Montevideo, Uruguay; Alumni Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. Electronic address: [email protected].
² Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. Electronic address: [email protected].

PMID: 32739290
DOI: 10.1016/j.bpobgyn.2020.07.004

Abstract

The high incidence of chromosome aneuploidy in human gametes and embryos is a major cause of in vitro fertilization (IVF) failure and miscarriage. In order to improve live birth rates with single embryo transfer, the use of preimplantation genetic testing for aneuploidy (PGT-A) has significantly increased. PGT encompasses methods that allow embryos to be tested for inherited conditions or screened for chromosomal abnormalities. However, PGT-A is a screening method and results can never be used to definitively predict the chromosomal status of the embryo and fetus. The objective of this manuscript is to review prenatal screening and diagnostic methods available in pregnancies conceived by IVF-PGT-A.

Keywords: Aneuploidy; CVS; Cell-free DNA; IVF; NIPT; PGT-A.

Publication types

Review

MeSH terms

Aneuploidy
Embryo Transfer
Female
Fertilization in Vitro
Genetic Testing
Humans
Pregnancy
Preimplantation Diagnosis*