Two pairs of bisabolane sesquiterpenoid stereoisomers, bisacurone D-G, from the rhizome of Curcuma longa L

Fitoterapia. 2020 Oct:146:104701. doi: 10.1016/j.fitote.2020.104701. Epub 2020 Aug 4.

Abstract

Phytochemical investigation of an extract of the rhizome of Curcuma longa L., resulted in the identification of four undescribed bisabolane sesquiterpenoids, namely as bisacurone D-G (1-4). With the aid of comprehensive spectroscopic techniques (NMR, IR, UV, MS), the structures of all isolated compounds were elucidated and subsequently screened for both anti-inflammatory and cytotoxic biological activities, Compounds 1 and 2 showed moderate inhibitory activity toward LPS-induced NO production on RAW 264.7 macrophages.

Keywords: Anti-inflammatory; Bisabolane sesquiterpenoids; Bisacurone D-G; Curcuma longa.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology
  • Cell Line, Tumor
  • China
  • Curcuma / chemistry*
  • Cyclohexanols
  • Humans
  • Mice
  • Molecular Structure
  • Monocyclic Sesquiterpenes / isolation & purification
  • Monocyclic Sesquiterpenes / pharmacology*
  • Nitric Oxide / metabolism
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Plant Extracts / chemistry
  • RAW 264.7 Cells
  • Rhizome / chemistry*
  • Sesquiterpenes

Substances

  • Anti-Inflammatory Agents
  • Cyclohexanols
  • Monocyclic Sesquiterpenes
  • Phytochemicals
  • Plant Extracts
  • Sesquiterpenes
  • bisacurone
  • Nitric Oxide