Could the antipsychotic chlorpromazine be a potential treatment for SARS-CoV-2?

Schizophr Res. 2020 Sep:223:373-375. doi: 10.1016/j.schres.2020.07.015. Epub 2020 Jul 25.
No abstract available

Keywords: Chlorpromazine; Clathrin-mediated endocytosis; SARS-CoV-2; Sedative medication; Viral replication.

Publication types

  • Letter

MeSH terms

  • Antipsychotic Agents / pharmacology*
  • Antipsychotic Agents / therapeutic use
  • COVID-19 Drug Treatment*
  • Chlorpromazine / pharmacology*
  • Chlorpromazine / therapeutic use
  • Clathrin-Coated Vesicles / drug effects*
  • Drug Repositioning
  • Endocytosis / drug effects*
  • Humans
  • Hydrogen-Ion Concentration / drug effects
  • In Vitro Techniques
  • Spike Glycoprotein, Coronavirus / drug effects*
  • Virus Internalization / drug effects*
  • Virus Replication / drug effects*

Substances

  • Antipsychotic Agents
  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2
  • Chlorpromazine