The Nike KrF laser facility was used to study the evolution of isolated defects with characteristic sizes of <1 to 10s of μm in laser-accelerated plastic foils. The experimental platform permitted, for the first time, the systematic study of localized perturbation growth, which is inherently multimode, through ablative Richtmyer-Meshkov and Rayleigh-Taylor stages and into the strongly nonlinear regime. Initial target defects were relatively large amplitude, but spatially localized, and emulated tent, fill-tube, and other nonuniformities that are present in inertial confinement fusion capsules. Face-on x-ray radiography indicated initial growth of the perturbation in both depth and width, followed by its apparent closure due to oblique spike growth. Hollow jetlike profiles of laterally expanding, rising, Rayleigh-Taylor bubbles were observed on the rear surface of the target from each isolated defect. Radiation hydrodynamic simulations provided insight into the mechanism of the closure and other features of the bubble and spike evolution specific to isolated defects.