One-Pot Synthesis of Indoles and Pyrazoles via Pd-Catalyzed Couplings/Cyclizations Enabled by Aqueous Micellar Catalysis

Org Lett. 2020 Aug 21;22(16):6543-6546. doi: 10.1021/acs.orglett.0c02315. Epub 2020 Aug 12.

Abstract

An effective one-pot synthesis of either indoles or pyrazoles can be achieved via Pd-catalyzed aminations followed by subsequent cyclizations facilitated by aqueous micellar catalysis. This new technology includes efficient couplings with low loadings of palladium, a more stable source of the required hydrazine moiety, greater atom economy for the initial coupling, and reduced reaction temperatures, all leading to environmentally responsible processes.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.