Eczema herpeticum is a disseminated cutaneous infection with herpes simplex virus (HSV) that develops in a patient with atopic dermatitis. This condition typically presents as a sudden onset eruption of monomorphic vesicles and "punched-out" erosions with hemorrhagic crusts over eczematous areas. Patients may have systemic symptoms like fever, lymphadenopathy, or malaise. Presentation ranges from mild and self-limiting in healthy adults to life-threatening in children, infants, and immunocompromised patients. Early treatment with antiviral therapy can shorten the duration of mild disease and prevent morbidity and mortality in severe cases.
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