Subclinical decrease in cardiac autonomic and diastolic function in patients with metabolic disorders: HSCAA study

Akiko Morimoto; Manabu Kadoya; Miki Kakutani-Hatayama; Kae Kosaka-Hamamoto; Akio Miyoshi; Takuhito Shoji; Akiko Goda; Masanori Asakura; Hidenori Koyama

doi:10.1016/j.metop.2020.100025

Subclinical decrease in cardiac autonomic and diastolic function in patients with metabolic disorders: HSCAA study

Metabol Open. 2020 Jan 22:5:100025. doi: 10.1016/j.metop.2020.100025. eCollection 2020 Mar.

Authors

Akiko Morimoto¹, Manabu Kadoya¹, Miki Kakutani-Hatayama¹, Kae Kosaka-Hamamoto¹, Akio Miyoshi¹, Takuhito Shoji¹, Akiko Goda², Masanori Asakura², Hidenori Koyama¹

Affiliations

¹ Division of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan.
² Division of Cardiovascular and Renal Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan.

Abstract

Heart failure due to decreased diastolic function, HFpEF, is a growing health concern with rising prevalence. We examined subclinical cardiac autonomic and diastolic functions in 605 patients with metabolic diseases classified as pre-heart failure. Presence of glucose intolerance or diabetes, or visceral adiposity was significantly associated with reduced cardiac autonomic and diastolic functions. Higher autonomic functions were significantly associated with a parameter of better cardiac diastolic function (E/A) (SDNN: r = 0.306, p < 0.01; HF: r = 0.341, p < 0.01), with the association independent of diabetes, body mass index, visceral adiposity and insulin resistance index. Thus, reduced autonomic function may be a potential predictor for decreased cardiac diastolic functions in metabolic disorders.

Keywords: Adiposity; Cardiac diastolic dysfunction; Diabetes; Glucose tolerance; Heart rate variability; Insulin resistance; Parasympathetic activity; Visceral obesity.