Photodynamic and sonodynamic therapy of acute hypoxemic respiratory failure in patients with COVID-19

Photodiagnosis Photodyn Ther. 2020 Sep:31:101961. doi: 10.1016/j.pdpdt.2020.101961. Epub 2020 Aug 17.

Abstract

  1. -

    COVID-19 is largely localized in lungs.

  2. -

    SARS-CoV-2 binds to the heme groups in hemoglobin that leads to severe hypoxia.

  3. -

    Porphyrin-based photosensitizers (PS) act as a ‘decoy’ in which the SARS-CoV-2 virions would attach to PS molecules.

  4. -

    Photoactivation capable of destroying the bonded SARS-CoV-2 virions.

Publication types

  • Letter

MeSH terms

  • Acute Disease
  • COVID-19
  • Cause of Death*
  • Coronavirus Infections / complications
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / drug therapy*
  • Critical Illness / mortality
  • Disease Progression
  • Female
  • Humans
  • Hypoxia / drug therapy*
  • Hypoxia / etiology
  • Male
  • Pandemics / statistics & numerical data
  • Photochemotherapy / methods*
  • Pneumonia, Viral / complications
  • Pneumonia, Viral / diagnosis
  • Pneumonia, Viral / drug therapy*
  • Respiratory Insufficiency / drug therapy*
  • Risk Assessment
  • Severe Acute Respiratory Syndrome / diagnosis
  • Severe Acute Respiratory Syndrome / drug therapy*
  • Severe Acute Respiratory Syndrome / epidemiology
  • Survival Analysis