Pharmacological aspects of therapy in inflammatory bowel diseases: antidiarrheal agents

J Clin Gastroenterol. 1988 Feb;10(1):57-63. doi: 10.1097/00004836-198802000-00013.

Abstract

We review the use of antidiarrheal medications in inflammatory bowel disease, commenting on potential underlying immunologic mechanisms as a background for discussion of the clinical usage of antidiarrheal medications in this disease spectrum. We comment on new directions for the development of more effective therapeutic approaches and discuss the mechanism of action of antidiarrheal drugs, with emphasis on synthetic opiates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antidiarrheals / pharmacology
  • Antidiarrheals / therapeutic use*
  • Colitis, Ulcerative / complications
  • Colitis, Ulcerative / drug therapy*
  • Colitis, Ulcerative / immunology
  • Crohn Disease / complications
  • Crohn Disease / drug therapy*
  • Crohn Disease / immunology
  • Diarrhea / drug therapy
  • Diarrhea / etiology
  • Humans

Substances

  • Antidiarrheals