Abstract
This article discusses the ontogeny of human T cells along with the relationship of normal T-cell maturation to the development of various malignant T-cell syndromes. The impact of monoclonal antibody technology, the discovery of the T-cell receptor for antigen, and the discovery of mechanisms of thymocyte-thymic microenvironment interactions on the analysis of human T-cell development are emphasized.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Antibodies, Monoclonal / immunology
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Antigens, Differentiation, T-Lymphocyte / immunology*
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Cell Differentiation
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Humans
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Immunoproliferative Disorders / immunology
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Receptors, Antigen, T-Cell / immunology*
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology*
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Thymus Gland / cytology*
Substances
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Antibodies, Monoclonal
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Antigens, Differentiation, T-Lymphocyte
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Receptors, Antigen, T-Cell