Background: The aim of this study was to summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19.
Methods: Available publications were systematically explored on some databases and gray literature was examined. Publications were discussed narratively.
Results: Remdesivir inhibits SARS-CoV-2 replication, reduces viral load, and exerts protective effects in SARS-CoV-2 infected animals. Remdesivir also reduces the pathological process, alleviates mild symptoms, and improves pulmonary lesions in SARS-CoV-2-infecetd animals. Remdesivir has been used as a compassionate drug for treating COVID-19 patients.
Conclusion: Although remdesivir has shown potent antiviral activities, more efficacy assessments are urgently warranted in clinical trials.
Keywords: COVID-19; Clinical trial; Remdesivir; SARS-CoV-2; Treatment.
© 2020 INDIACLEN. Published by Elsevier, a division of RELX India, Pvt. Ltd.