Complement-mediated oxidative damage of red cells impairs response to eculizumab in a G6PD-deficient patient with PNH

MeSH terms

• Adult
• Antibodies, Monoclonal, Humanized* / administration & dosage
• Antibodies, Monoclonal, Humanized* / adverse effects
• Complement System Proteins / metabolism*
• Erythrocytes* / metabolism
• Erythrocytes* / pathology
• Female
• Glucosephosphate Dehydrogenase Deficiency* / drug therapy
• Glucosephosphate Dehydrogenase Deficiency* / genetics
• Glucosephosphate Dehydrogenase Deficiency* / metabolism
• Hemoglobinuria, Paroxysmal* / drug therapy
• Hemoglobinuria, Paroxysmal* / metabolism
• Hemoglobinuria, Paroxysmal* / pathology
• Humans
• Oxidative Stress / drug effects*