Can FDG-PET/MR help to overcome limitations of sequential MRI and PET-FDG for differential diagnosis between recurrence/progression and radionecrosis of high-grade gliomas?

N Pyatigorskaya; B Sgard; M Bertaux; L Yahia-Cherif; A Kas

doi:10.1016/j.neurad.2020.08.003

Can FDG-PET/MR help to overcome limitations of sequential MRI and PET-FDG for differential diagnosis between recurrence/progression and radionecrosis of high-grade gliomas?

J Neuroradiol. 2021 May;48(3):189-194. doi: 10.1016/j.neurad.2020.08.003. Epub 2020 Aug 25.

Authors

N Pyatigorskaya¹, B Sgard², M Bertaux², L Yahia-Cherif³, A Kas⁴

Affiliations

¹ Sorbonne Université, Assistance Publique Hôpitaux de Paris, Neuroradiology Department, Pitié-Salpêtrière -Charles Foix Hospital, Paris, France; Sorbonne Université, Univ Paris 6, UMR S 1127, CNRS UMR 722, Institut du Cerveau et de la Moelle épinière, F-75013 Paris, France. Electronic address: [email protected].
² Assistance Publique Hôpitaux de Paris, Nuclear Medicine Department, Pitié Salpêtrière-Charles Foix Hospital, AP-HP, 47-83 Boulevard de l'Hôpital, 75651 Paris CEDEX 13, France.
³ Sorbonne Université, Univ Paris 6, UMR S 1127, CNRS UMR 722, Institut du Cerveau et de la Moelle épinière, F-75013 Paris, France.
⁴ Assistance Publique Hôpitaux de Paris, Nuclear Medicine Department, Pitié Salpêtrière-Charles Foix Hospital, AP-HP, 47-83 Boulevard de l'Hôpital, 75651 Paris CEDEX 13, France; Sorbonne University, Laboratoire d'Imagerie Biomédicale, INSERM U1146, Paris, France.

PMID: 32858062
DOI: 10.1016/j.neurad.2020.08.003

Abstract

The aim of our study was assessing the potential of FDG-PET-MRI to overcome limitations of separately performed MRI and PET-FDG and improving the performance of high-grade gliomas evaluation. Combined PET-MRI analysis allowed differentiating between recurrence/progression and radionecrosis with improved diagnostic accuracy (95% vs 63% for PET and 82% for MRI). FDG being a reliable, cost-saving tracer in this indication, combined FDG PET-MRI analysis could play a significant role in the follow-up of high-grade brain tumors.

Keywords: ASL; FDG; PET-MRI; glioblastoma.

MeSH terms

Brain Neoplasms* / diagnostic imaging
Diagnosis, Differential
Fluorodeoxyglucose F18
Glioma* / diagnostic imaging
Humans
Magnetic Resonance Imaging
Positron-Emission Tomography
Radiopharmaceuticals

Substances

Radiopharmaceuticals
Fluorodeoxyglucose F18