Transfer of daclatasvir and sofosbuvir's main metabolite, GS-331007, across the human placenta ex vivo

MeSH terms

• Antiviral Agents / metabolism
• Antiviral Agents / pharmacokinetics*
• Carbamates / metabolism
• Carbamates / pharmacokinetics*
• Female
• Hepatitis C / drug therapy
• Humans
• Imidazoles / metabolism
• Imidazoles / pharmacokinetics*
• Maternal-Fetal Exchange*
• Placenta / metabolism*
• Pregnancy
• Pregnancy Complications, Infectious / drug therapy
• Pyrrolidines / metabolism
• Pyrrolidines / pharmacokinetics*
• Sofosbuvir / metabolism
• Sofosbuvir / pharmacokinetics
• Uridine / analogs & derivatives*
• Uridine / metabolism
• Uridine / pharmacokinetics
• Valine / analogs & derivatives*
• Valine / metabolism
• Valine / pharmacokinetics