The Influence of the Cholesterol Level in Cells on Endovanilloid Cytotoxicity

M G Akimov; P V Dudina; A M Gamisonia; N M Gretskaya; G N Zinchenko; C C Mandal; V V Bezuglov

doi:10.1134/S1607672920040018

The Influence of the Cholesterol Level in Cells on Endovanilloid Cytotoxicity

Dokl Biochem Biophys. 2020 Jul;493(1):167-170. doi: 10.1134/S1607672920040018. Epub 2020 Sep 7.

Authors

M G Akimov¹, P V Dudina², A M Gamisonia², N M Gretskaya², G N Zinchenko², C C Mandal³, V V Bezuglov²

Affiliations

¹ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia. [email protected].
² Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
³ School of Life Sciences, Central University of Rajasthan, NH 8, Bandarsindri, 305817, Ajmer, Kishangarh, Rajasthan, India.

PMID: 32894457
DOI: 10.1134/S1607672920040018

Abstract

The influence of the cellular cholesterol content on the cytotoxicity of endovanilloids acyldopamines was studied in MDA-MB-231 and MCF 10A cells. The activity of acyldopamines depends on the cellular cholesterol content, and a decrease in cholesterol content increases the cytotoxicity of acyldopamines.

Keywords: acyldopamine cytotoxicity; arachidonoyl dopamine; cholesterol; endocannabinoids; endovanilloids.

MeSH terms

Anticholesteremic Agents / pharmacology
Apoptosis
Atorvastatin / pharmacokinetics*
Atorvastatin / pharmacology
Breast Neoplasms / drug therapy
Breast Neoplasms / metabolism
Breast Neoplasms / pathology*
Cholesterol / metabolism*
Dopamine / analogs & derivatives*
Dopamine / pharmacology
Female
Humans
Receptors, Cannabinoid / metabolism
Tumor Cells, Cultured

Substances

Anticholesteremic Agents
Receptors, Cannabinoid
Cholesterol
Atorvastatin
Dopamine