Mechanisms and Functions of Mitophagy and Potential Roles in Renal Disease

Zhenying Zuo; Kaipeng Jing; Hongluan Wu; Shujun Wang; Lin Ye; Zhihang Li; Chen Yang; Qingjun Pan; Wei Jing Liu; Hua-Feng Liu

doi:10.3389/fphys.2020.00935

Mechanisms and Functions of Mitophagy and Potential Roles in Renal Disease

Front Physiol. 2020 Aug 7:11:935. doi: 10.3389/fphys.2020.00935. eCollection 2020.

Authors

Zhenying Zuo¹, Kaipeng Jing^{1

2}, Hongluan Wu^{1

2}, Shujun Wang^{1

2}, Lin Ye¹, Zhihang Li¹, Chen Yang^{1

2}, Qingjun Pan^{1

2}, Wei Jing Liu^{1

3

4}, Hua-Feng Liu^{1

2}

Affiliations

¹ Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
² Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
³ Key Laboratory of Chinese Internal Medicine, Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
⁴ Renal Research Institution of Beijing University of Chinese Medicine, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.

Abstract

Mitophagy is an evolutionarily conserved process to selectively remove damaged or unnecessary mitochondria via the autophagic machinery. In this review, we focus on recent advances in the molecular mechanisms of mitophagy and how mitophagy contributes to cellular homeostasis in physiological and pathological contexts. We also briefly review and discuss the crosstalk between mitophagy and renal disease, highlighting its modulation as a potentially effective therapeutic strategy to treat kidney diseases such as acute kidney injury (AKI), diabetic kidney disease (DKD), and lupus nephritis (LN).

Keywords: acute kidney injury; diabetic kidney disease; lupus nephritis; mitochondrial dysfunction; mitophagy.

Publication types

Review