Surface functionalization of PEEK with silicon nitride

Francesco Boschetto; Elia Marin; Eriko Ohgitani; Tetsuya Adachi; Matteo Zanocco; Satoshi Horiguchi; Wenliang Zhu; Bryan J McEntire; Osam Mazda; B Sonny Bal; Giuseppe Pezzotti

doi:10.1088/1748-605X/abb6b1

Surface functionalization of PEEK with silicon nitride

Biomed Mater. 2020 Dec 11;16(1). doi: 10.1088/1748-605X/abb6b1.

Authors

Francesco Boschetto^{1

2}, Elia Marin^{1

3}, Eriko Ohgitani², Tetsuya Adachi³, Matteo Zanocco^{1

3}, Satoshi Horiguchi³, Wenliang Zhu¹, Bryan J McEntire⁴, Osam Mazda², B Sonny Bal⁴, Giuseppe Pezzotti^{1

2

5

6}

Affiliations

¹ Ceramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki 606-8585, Kyoto, Japan.
² Department of Immunology, Kyoto Prefectural University of Medicine, Kamigyo-ku 602-8566, Kyoto, Japan.
³ Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan.
⁴ SINTX Technologies, Co., 1885 West 2100 South, Salt Lake City, UT 84119, United States of America.
⁵ Department of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku 160-0023, Tokyo, Japan.
⁶ The Center for Advanced Medical Engineering and Informatics, Osaka University, Yamadaoka Suita 565-0871, Osaka, Japan.

PMID: 32906100
DOI: 10.1088/1748-605X/abb6b1

Abstract

Surface roughness, bioactivity, and antibacterial properties are desirable in skeletal implants. We hot-pressed a mix of particulate sodium chloride (NaCl) salt and silicon nitride (β-Si₃N₄) onto the surface of bulk PEEK. NaCl grains were removed by leaching in water, resulting in a porous PEEK surface embedded with sim15 vol% β-Si₃N₄particles. This functionalized surface showed the osteogenic and antibacterial properties previously reported in bulk silicon nitride implants. Surface enhancement of PEEK with β-Si₃N₄could improve the performance of spinal fusion cages, by facilitating arthrodesis and resisting bacteria.

Keywords: PEEK; bacteriostasis; osteogenesis; silicon nitride; surface functionalization.

MeSH terms

Anti-Bacterial Agents* / chemistry
Anti-Bacterial Agents* / pharmacology
Bacteria / drug effects
Benzophenones* / chemistry
Benzophenones* / pharmacology
Biocompatible Materials* / chemistry
Biocompatible Materials* / pharmacology
Cell Line, Tumor
Cell Proliferation / drug effects
Humans
Materials Testing
Osteogenesis / drug effects
Polymers* / chemistry
Polymers* / pharmacology
Prostheses and Implants / microbiology
Silicon Compounds* / chemistry
Silicon Compounds* / pharmacology
Sodium Chloride / chemistry
Surface Properties

Substances

Anti-Bacterial Agents
Benzophenones
Biocompatible Materials
Polymers
Silicon Compounds
polyetheretherketone
Sodium Chloride
silicon nitride