Drag-reducing polymers improve hepatic vaso-occlusion in SCD mice

Blood Adv. 2020 Sep 22;4(18):4333-4336. doi: 10.1182/bloodadvances.2020002779.

Authors

Dan Crompton^{1

2}, Ravi Vats^{1

3}, Tirthadipa Pradhan-Sundd³, Prithu Sundd^{1

3

4}, Marina V Kameneva^{1

2

5}

Affiliations

¹ Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA.
² McGowan Center for Regenerative Medicine, Pittsburgh, PA.
³ Pittsburgh Heart, Lung and Blood Vascular Medicine Institute and.
⁴ Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA; and.
⁵ Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.

Abstract

Nanomolar concentrations of drag-reducing polymer (DRP) reduce vaso-occlusion in the liver of sickle cell disease (SCD) mice.
The potential for DRP as a rheology-based treatment/therapy for SCD warrants further study.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Anemia, Sickle Cell*
Animals
Mice
Polymers
Vascular Diseases*

Substances

Polymers

Grants and funding