Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Avidity Maturation and Association with Disease Severity

Yiqi Ruben Luo; Indrani Chakraborty; Cassandra Yun; Alan H B Wu; Kara L Lynch

doi:10.1093/cid/ciaa1389

Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Avidity Maturation and Association with Disease Severity

Clin Infect Dis. 2021 Nov 2;73(9):e3095-e3097. doi: 10.1093/cid/ciaa1389.

Authors

Yiqi Ruben Luo¹, Indrani Chakraborty², Cassandra Yun¹, Alan H B Wu¹, Kara L Lynch¹

Affiliations

¹ Department of Laboratory Medicine, University of California San Francisco and Zuckerberg San Francisco General Hospital, San Francisco, California, USA.
² Gator Bio, Palo Alto, California, USA.

Abstract

The kinetics of IgG avidity maturation during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was studied. The IgG avidity assay, using a novel label-free immunoassay technology, revealed a strong correlation between IgG avidity and days since symptom onset. Peak readings were significantly higher in severe than mild disease cases.

Keywords: COVID-19; SARS-CoV-2; antibody avidity; label-free immunoassay; thin-film interferometry.

MeSH terms

Antibodies, Viral
Antibody Affinity
COVID-19*
Humans
Immunoglobulin G
Immunoglobulin M
Kinetics
SARS-CoV-2*
Severity of Illness Index

Substances

Antibodies, Viral
Immunoglobulin G
Immunoglobulin M