Multisystem Inflammatory Syndrome Associated With COVID-19 With Neurologic Manifestations in a Child: A Brief Report

Pediatr Infect Dis J. 2020 Oct;39(10):e321-e324. doi: 10.1097/INF.0000000000002834.

Abstract

Although first considered a benign infection, recent studies have disclosed severe and potentially lethal inflammatory manifestations of COVID-19 in children. We report the case of a 4-year-old child with a post-infectious multisystem inflammatory syndrome associated with COVID-19, with a Kawasaki-like shock and prominent neurologic features, for whom a cytokine storm and reduced brain-derived neurotrophic factor were well documented.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Viral / blood
  • Betacoronavirus / immunology
  • Brain-Derived Neurotrophic Factor / blood
  • COVID-19
  • Child, Preschool
  • Coronavirus Infections / complications*
  • Cytokines / blood
  • Female
  • Humans
  • Immunoglobulin G / blood
  • Inflammation
  • Pandemics
  • Pneumonia, Viral / complications*
  • SARS-CoV-2
  • Systemic Inflammatory Response Syndrome / complications*
  • Systemic Inflammatory Response Syndrome / pathology
  • Systemic Inflammatory Response Syndrome / virology

Substances

  • Antibodies, Viral
  • Brain-Derived Neurotrophic Factor
  • Cytokines
  • Immunoglobulin G