L1 drives HSC aging and affects prognosis of chronic myelomonocytic leukemia

Ying Wang; Jin-Ping Zheng; Ying Luo; Junyi Wang; Lingjie Xu; Jinyong Wang; John M Sedivy; Zhangfa Song; Hu Wang; Zhenyu Ju

doi:10.1038/s41392-020-00279-4

L1 drives HSC aging and affects prognosis of chronic myelomonocytic leukemia

Signal Transduct Target Ther. 2020 Sep 19;5(1):205. doi: 10.1038/s41392-020-00279-4.

Authors

Ying Wang^#¹, Jin-Ping Zheng^#², Ying Luo³, Junyi Wang⁴, Lingjie Xu⁴, Jinyong Wang⁵, John M Sedivy⁶, Zhangfa Song⁷, Hu Wang^{8

9}, Zhenyu Ju^{10

11}

Affiliations

¹ Key Laboratory of Aging and Cancer Biology of Zhejiang Province, Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, 311121, China. [email protected].
² Department of Public Health and Preventive Medicine, Changzhi Medical College, Changzhi, Shanxi, 046000, P. R. China.
³ Key Laboratory of Regenerative Medicine of Ministry of Education, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, 510632, China.
⁴ Key Laboratory of Aging and Cancer Biology of Zhejiang Province, Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, 311121, China.
⁵ CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
⁶ Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, 02903, USA.
⁷ Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China. [email protected].
⁸ Key Laboratory of Aging and Cancer Biology of Zhejiang Province, Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, 311121, China. [email protected].
⁹ Key Laboratory of Regenerative Medicine of Ministry of Education, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, 510632, China. [email protected].
¹⁰ Key Laboratory of Aging and Cancer Biology of Zhejiang Province, Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, 311121, China. [email protected].
¹¹ Key Laboratory of Regenerative Medicine of Ministry of Education, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, 510632, China. [email protected].

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cellular Senescence*
Hematopoietic Stem Cells / metabolism*
Hematopoietic Stem Cells / pathology
Leukemia, Myelomonocytic, Chronic / genetics
Leukemia, Myelomonocytic, Chronic / metabolism*
Leukemia, Myelomonocytic, Chronic / pathology
Mice
Mice, Knockout
Retroelements*

Substances

Retroelements

Grants and funding

P01 AG051449/AG/NIA NIH HHS/United States