Inactivation of ApoC3 by CRISPR/Cas9 Protects Against Atherosclerosis in Hamsters

Circ Res. 2020 Nov 6;127(11):1456-1458. doi: 10.1161/CIRCRESAHA.120.317686. Epub 2020 Sep 21.
No abstract available

Keywords: apolipoprotein; atherosclerosis; cardiovascular disease; lipoprotein lipase; mice.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apolipoprotein C-III / deficiency
  • Apolipoprotein C-III / genetics*
  • Atherosclerosis / genetics
  • Atherosclerosis / metabolism
  • Atherosclerosis / pathology
  • Atherosclerosis / prevention & control*
  • Biomarkers / blood
  • CRISPR-Associated Protein 9 / genetics*
  • CRISPR-Associated Protein 9 / metabolism
  • CRISPR-Cas Systems*
  • Clustered Regularly Interspaced Short Palindromic Repeats*
  • Diet, High-Fat
  • Disease Models, Animal
  • Gene Deletion*
  • Genetic Therapy*
  • Lipids / blood
  • Mesocricetus
  • Plaque, Atherosclerotic

Substances

  • Apolipoprotein C-III
  • Biomarkers
  • Lipids
  • CRISPR-Associated Protein 9