Abstract
In this issue of Blood, articles by Manne et al and Hottz et al highlight platelet hyperactivity in COVID-19–associated pathophysiology., Although the hallmarks of COVID-19 include a brisk inflammatory response and respiratory symptoms, the hematologic manifestations of this infection have also garnered attention, with thrombotic complications taking center stage., COVID-19–associated coagulopathy has been characterized by an elevated D-dimer, mild thrombocytopenia, and a prolongation of the activated partial thromboplastin time. Alongside these laboratory abnormalities, patients present with increased rates of thrombosis. The role of platelets in the thrombotic complications of COVID-19 is explored in these 2 articles, establishing that platelet hyperactivity contributes to the coagulopathy seen in COVID-19.
MeSH terms
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Betacoronavirus
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Blood Platelets*
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COVID-19
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Coronavirus Infections*
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Humans
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Pandemics*
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Platelet Aggregation
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Pneumonia, Viral*
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SARS-CoV-2