Objective: To evaluate the oncologic outcomes of different laparoscopic radical hysterectomy. Methods: From January 2011 to December 2014, the laparoscopic operation cases of cervical cancer at stage Ⅰb1, Ⅰb2, Ⅱa1 and Ⅱa2, including the histologic subtypes of squamous-cell carcinoma, adenocarcinoma and adenosquamous carcinoma, were collected in five clinical centers. The data were divided into two groups according to the surgical procedures, that is, modified laparoscopic-vaginal radical hysterectomy (mLVRH) and total laparoscopic radical hysterectomy (TLRH). The overall survival rate (OS), disease-free survival rate (DFS) at 5 years were retrospectively analyzed in this study. Results: There were 674 cases in total, including 377 cases of mLVRH, 297 cases of TLRH. (1) The OS at 5 years: the mLVRH was 96.1% and the TLRH was 92.0%, and the mLVRH was higher than that of TLRH （P=0.010）. Stratify analysis， including stage of disease （Ⅰb1 and Ⅱa1）， histologic subtypes （squamous-cell carcinoma, adenocarcinoma）， lymph node metastasis， revealed that, ① Stage of disease: in stage Ⅰb1, the OS at five years of mLVRH was higher than that in TLRH group （98.6% vs 93.6%, P=0.012）. In stage Ⅱa1, there was significant difference between the two groups, the OS at five years of mLVRH and TLRH were 93.6% and 77.6% （P=0.007）. ② Histologic subtypes: for the OS at five years of squamous-cell carcinoma, mLVRH and TLRH were 96.1% and 92.3%, and there was significant difference （P=0.046）； for adenocarcinoma, the OS at five years were 91.0% and 88.6%， and there was no difference between two groups （P=0.230）. ③ Lymph node metastasis： the mLVRH and TLRH with lymph node metastasis, the OS at five years were 98.6% and 96.4%; the mLVRH and TLRH without lymph node metastasis, the OS at five years were 89.3% and 80.8%. There were no significant differences between the two groups,respectively (P=0.156， P=0.093）. (2) The DFS at 5 years: there was no significant difference between mLVRH and TLRH (94.1% vs 90.9%, P=0.220). Stratify analysis for stage of disease, the mLVRH group was higher than that in the TLRH group in stage Ⅰb1 (97.0% vs 92.8%, P=0.039). However, for stage Ⅱa1, there was no significant difference between mLVRH and TLRH group （88.2% vs 75.8%, P=0.074）. Conclusions: The results of this retrospective study indicated that different laparoscopy surgical procedures had diverse oncologic outcomes. The OS at 5 years of the mLVRH is superior to the TLRH. The DFS at 5 years in Ⅰb1 stage, the mLVRH is higher than the TLRH. Therefore, the modified laparoscopy is still an alternative surgery for early cervical cancer patients when following the principle of no-tumor-exposure.
目的： 探讨不同腹腔镜手术方式治疗早期子宫颈癌的肿瘤学结局的差异。 方法： 收集2011年1月—2014年12月在国内6家医疗中心接受腹腔镜手术的子宫颈癌患者，临床分期为Ⅰb1、Ⅰb2、Ⅱa1、Ⅱa2期，病理类型为鳞癌、腺癌、腺鳞癌，有定期随访资料。按照手术方式不同分为两组，包括改良经阴道辅助腹腔镜手术（改良腹腔镜组）、完全腹腔镜手术（完全腹腔镜组），比较两种手术方式的5年总生存率（OS）、5年无瘤生存率（DFS）等肿瘤学结局指标。 结果： 共有674例子宫颈癌患者纳入本研究，其中改良腹腔镜组377例、完全腹腔镜组297例。（1）两组5年OS 的比较：改良腹腔镜组、完全腹腔镜组患者的5年OS分别为96.1%、92.0%，改良腹腔镜组显著高于完全腹腔镜组（P=0.010）。进一步对临床分期（包括Ⅰb1、Ⅱa1期）、病理类型（鳞癌、腺癌）、淋巴结转移进行分层分析，结果显示，①临床分期：Ⅰb1患者的5年OS，改良腹腔镜组、完全腹腔镜组分别为98.6%、93.6%，两组比较，差异有统计学意义（P=0.012）；Ⅱa1期患者的5年OS，改良腹腔镜组、完全腹腔镜组分别为93.6%、77.6%，两组比较，差异也有统计学意义（P=0.007）。②病理类型：改良腹腔镜组、完全腹腔镜组鳞癌患者的5年OS分别为96.1%、92.3%，两组比较，差异有统计学意义（P=0.046）；腺癌患者的5年OS分别为91.0%、88.6%，两组比较，差异无统计学意义（P=0.230）。③淋巴结转移：改良腹腔镜组、完全腹腔镜组无淋巴转移患者的5年OS分别为98.6%、96.4%，有淋巴结转移患者的5年OS分别为89.3%、80.8%，两组分别比较，差异均无统计学意义（P=0.156，P=0.093）。（2）两组5年DFS的比较：改良腹腔镜组、完全腹腔镜组患者的5年DFS分别为94.1%、90.9%，两组比较，差异无统计学意义（P=0.220）。进一步对临床分期进行分层分析，结果显示，Ⅰb1期患者的5年DFS，改良腹腔镜组和完全腹腔镜组分别为97.0%、92.8%，两组比较，差异有统计学意义（P=0.039）；Ⅱa1期患者的5年DFS，改良腹腔镜组、完全腹腔镜组分别为88.2%、75.8%，两组比较，差异无统计学意义（P=0.074）。 结论： 不同腹腔镜手术方式可影响早期子宫颈癌患者的肿瘤学结局，改良经阴道辅助腹腔镜手术患者的5年OS高于完全腹腔镜手术患者，且其中Ⅰb1期患者的5年DFS也高于完全腹腔镜手术患者。提示，基于无瘤原则的改良经阴道腹腔镜手术仍可作为早期子宫颈癌手术治疗的选择。.
Keywords: Cervical cancer; Laparoscopy; Outcome; Retrospective study; The survival rate.