Endotheliopathy Is Induced by Plasma From Critically Ill Patients and Associated With Organ Failure in Severe COVID-19

Antoine Rauch; Annabelle Dupont; Julien Goutay; Morgan Caplan; Senna Staessens; Mouhamed Moussa; Emmanuelle Jeanpierre; Delphine Corseaux; Guillaume Lefevre; Fanny Lassalle; Karine Faure; Marc Lambert; Alain Duhamel; Julien Labreuche; Delphine Garrigue; Simon F De Meyer; Bart Staels; Eric Van Belle; Flavien Vincent; Eric Kipnis; Peter J Lenting; Julien Poissy; Sophie Susen; Lille COVID Research Network (LICORNE); Members of the LICORNE Scientific Committee

doi:10.1161/CIRCULATIONAHA.120.050907

Endotheliopathy Is Induced by Plasma From Critically Ill Patients and Associated With Organ Failure in Severe COVID-19

Circulation. 2020 Nov 10;142(19):1881-1884. doi: 10.1161/CIRCULATIONAHA.120.050907. Epub 2020 Sep 24.

Authors

Antoine Rauch^#¹, Annabelle Dupont^#¹, Julien Goutay², Morgan Caplan², Senna Staessens^{3

4}, Mouhamed Moussa^{1

5}, Emmanuelle Jeanpierre¹, Delphine Corseaux^{1

3}, Guillaume Lefevre⁶, Fanny Lassalle¹, Karine Faure⁷, Marc Lambert⁸, Alain Duhamel⁶, Julien Labreuche⁶, Delphine Garrigue⁹, Simon F De Meyer⁴, Bart Staels^{1

3}, Eric Van Belle^{1

10}, Flavien Vincent¹, Eric Kipnis³, Peter J Lenting, Julien Poissy¹¹, Sophie Susen¹; Lille COVID Research Network (LICORNE); Members of the LICORNE Scientific Committee

Collaborators

Dominique Deplanque, Enagnon Kazali Alidjinou, Régis Bordet, Marie-Charlotte Chopin, Ilka Engelmann, Anne Goffard, Myriam Labalette, David Launay, Daniel Mathieu, Claude-Alain Maurage, Boualem Sendid

Affiliations

¹ Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, F-59000 Lille, France (A.R., A. Dupont, M.M., E.J., D.C., F.L., B.S., E.V.B., F.V., S. Susen).
² Intensive Care Department, Pôle de Réanimation (J.G., M.C.), Centre Hospitalier Universitaire Lille, France.
³ Centre national de la recherche scientifique, Surgical Critical Care, Department of Anesthesiology and Critical Care, U1019 - Unité mixte de recherche 9017 - Center for Infection and Immunity of Lille (E.K.), Institut Pasteur de Lille, UMR1011-EGID (S. Staessens, D.C., B.S.), Univ. Lille, CHU Lille, France.
⁴ Laboratory for Thrombosis Research, Katholieke Universiteit Leuven Campus Kulak Kortrijk, Belgium (S. Staessens, S.F.D.M.).
⁵ Surgical Critical Care, Department of Anesthesiology and Critical Care (M.M.), Univ. Lille, CHU Lille, France.
⁶ Institut d'Immunologie, U1286 - INFINITE - Institute for Translational Research in Inflammation (G.L.), ULR 2694 - METRICS: Évaluation des technologies de santé et des pratiques médicales (A. Duhamel, J.L.), Univ. Lille, CHU Lille, France.
⁷ Department of Infectious Diseases (K.F.), Univ. Lille, CHU Lille, France.
⁸ Department of Internal Medicine, Institut national de la santé et de la recherche médicale U 1167 (M.L.), Univ. Lille, CHU Lille, France.
⁹ Surgical Critical Care, Department of Anesthesiology and Critical Care (D.G.), Centre Hospitalier Universitaire Lille, France.
¹⁰ Department Cardiology (E.V.B., F.V.), Univ. Lille, CHU Lille, France.
¹¹ Institut national de la santé et de la recherche médicale U1285, Pôle de réanimation, Centre national de la recherche scientifique, Unité mixte de recherche 8576 - Unité de Glycobiologie Structurale et Fonctionnelle (J.P.), Univ. Lille, CHU Lille, France.

^# Contributed equally.

No abstract available

Keywords: SARS-CoV-2; cell death; endothelial cell; endotheliopathy; liver injury; renal failure; respiratory failure.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Betacoronavirus / isolation & purification
COVID-19
Cell Survival
Cell-Free Nucleic Acids / metabolism
Cells, Cultured
Coronavirus Infections / complications
Coronavirus Infections / pathology*
Coronavirus Infections / virology
Critical Illness
Endothelial Cells / cytology
Endothelial Cells / metabolism
Humans
Interleukin-6 / metabolism
Microvessels / cytology
Multiple Organ Failure / etiology
Pandemics
Plasma / chemistry*
Plasma / metabolism
Pneumonia, Viral / complications
Pneumonia, Viral / pathology*
Pneumonia, Viral / virology
SARS-CoV-2
Severity of Illness Index
Syndecan-1 / metabolism

Substances

Cell-Free Nucleic Acids
Interleukin-6
Syndecan-1