Anti-synthetase syndrome (ASS) is a rare autoimmune disorder characterized by the presence of antibodies against aminoacyl-transfer RNA synthetase commonly associated inflammatory myopathy. In this case report, we describe an adult female with NMOSD concurrent with ASS in which the lesion involved the entire length of the spinal cord. Since B-cell mediated molecular pathway is involved in the pathogenesis of NMOSD and ASS, we suggest that the therapeutically targeted killing of B-cells, such as Rituximab, is effective.
Keywords: Anti- SSA/Ro52 antibody; Anti-Jo-1 antibody; Anti-synthetase syndrome; Longitudinally extensive transverse myelitis; Neuromyelitis optica spectrum disorder.
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