PPHN and oxidative stress: a review of literature

R Chimenz; L Cannavò; A Gasbarro; F Nascimben; S Sestito; L Rizzuti; G Ceravolo; M D Ceravolo; M P Calabrò; C Romeo; E Gitto

PPHN and oxidative stress: a review of literature

J Biol Regul Homeost Agents. 2020 Jul-Aug;34(4 Suppl. 2):79-83. SPECIAL ISSUE: FOCUS ON PEDIATRIC CARDIOLOGY.

Authors

R Chimenz¹, L Cannavò², A Gasbarro², F Nascimben³, S Sestito⁴, L Rizzuti², G Ceravolo⁵, M D Ceravolo⁵, M P Calabrò⁶, C Romeo³, E Gitto²

Affiliations

¹ Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", Unit of Pediatric Nephrology and Rheumatology with Dialysis, University of Messina, "G. Martino" Policlinic, Italy.
² Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", Neonatal and Pediatric Intensive Care Unit, University of Messina, Messina, Italy.
³ Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", Pediatric Surgery Unit, University of Messina, Messina, Italy.
⁴ Department of Science of Health, University Magna Graecia of Catanzaro, Pediatric Unit, University of Catanzaro, Italy.
⁵ Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", Unit of Emergency Pediatrics, University of Messina, "G. Martino" Policlinic, Messina, Italy.
⁶ Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", Unit of Pediatric Cardiology, University of Messina, "G. Martino" Policlinic, Italy.

PMID: 33000605

Abstract

Persistent pulmonary hypertension of the neonate is a multifactorial condition characterized by maladaptive pulmonary vascular remodeling and abnormal contractile reactivity. This review evaluates the role of oxidative stress and antioxidant treatment on the persistent pulmonary hypertension of the neonate.

Keywords: Persistent pulmonary hypertension; melatonin; oxidative stress.

Publication types

Review

MeSH terms

Antioxidants
Humans
Infant, Newborn
Oxidative Stress*
Persistent Fetal Circulation Syndrome

Substances

Antioxidants