Cholestatic Liver Diseases: A Primer for Generalists and Subspecialists

Moira B Hilscher; Patrick S Kamath; John E Eaton

doi:10.1016/j.mayocp.2020.01.015

Cholestatic Liver Diseases: A Primer for Generalists and Subspecialists

Mayo Clin Proc. 2020 Oct;95(10):2263-2279. doi: 10.1016/j.mayocp.2020.01.015.

Authors

Moira B Hilscher¹, Patrick S Kamath¹, John E Eaton²

Affiliations

¹ Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.
² Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN. Electronic address: [email protected].

PMID: 33012354
DOI: 10.1016/j.mayocp.2020.01.015

Abstract

Cholestasis describes impairment in bile formation or flow which can manifest clinically with fatigue, pruritus, and jaundice. The differential diagnosis of cholestatic liver diseases is broad, and the etiologies of cholestasis vary in the anatomical location of the defect and acuity of presentation. Cholestasis may occur in a variety of clinical scenarios. Therefore, it is important for a diverse audience with varied clinical practices to have a basic understanding of manifestations of cholestatic liver diseases.

Publication types

Review

MeSH terms

Cholestasis / complications
Cholestasis / diagnosis*
Cholestasis / etiology
Decision Trees
Diagnosis, Differential
General Practice
Humans
Liver Diseases / diagnosis*
Liver Diseases / etiology
Medicine