Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome

Front Endocrinol (Lausanne). 2020 Sep 9:11:641. doi: 10.3389/fendo.2020.00641. eCollection 2020.

Abstract

Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the role of AMH in the trans-generational transmission of PCOS. For each of those issues, the clinical and experimental evidences currently available are discussed and pathophysiological hypothesis are proposed.

Keywords: FSH; GnRH; androgens; anovulation; anti-müllerian hormone; aromatase; follicle; polycystic ovary syndrome.

Publication types

  • Review

MeSH terms

  • Anti-Mullerian Hormone / metabolism*
  • Female
  • Follicle Stimulating Hormone / metabolism
  • Humans
  • Luteinizing Hormone / metabolism
  • Ovarian Follicle / metabolism*
  • Polycystic Ovary Syndrome / metabolism*

Substances

  • Anti-Mullerian Hormone
  • Luteinizing Hormone
  • Follicle Stimulating Hormone