Standardized definitions for evaluation of heart failure therapies: scientific expert panel from the Heart Failure Collaboratory and Academic Research Consortium

Eur J Heart Fail. 2020 Dec;22(12):2175-2186. doi: 10.1002/ejhf.2018. Epub 2020 Nov 13.

Abstract

The Heart Failure Academic Research Consortium is a partnership between the Heart Failure Collaboratory (HFC) and Academic Research Consortium (ARC), comprised of leading heart failure (HF) academic research investigators, patients, United States (US) Food and Drug Administration representatives, and industry members from the US and Europe. A series of meetings were convened to establish definitions and key concepts for the evaluation of HF therapies including optimal medical and device background therapy, clinical trial design elements and statistical concepts, and study endpoints. This manuscript summarizes the expert panel discussions as consensus recommendations focused on populations and endpoint definitions; it is not exhaustive or restrictive, but designed to stimulate HF clinical trial innovation.

Keywords: Clinical trial; Definitions; Endpoints; Heart failure.

Publication types

  • Practice Guideline
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cardiac Resynchronization Therapy
  • Cardiovascular Agents / therapeutic use
  • Clinical Trials as Topic / standards*
  • Comorbidity
  • Consensus
  • Defibrillators, Implantable
  • Diagnostic Techniques, Cardiovascular / standards
  • Electric Countershock / instrumentation
  • Endpoint Determination / standards
  • Europe
  • Heart Failure* / diagnosis
  • Heart Failure* / epidemiology
  • Heart Failure* / etiology
  • Heart Failure* / therapy
  • Hospitalization
  • Humans
  • Patient Reported Outcome Measures
  • Quality of Life
  • Terminology as Topic*
  • Treatment Outcome
  • United States

Substances

  • Cardiovascular Agents