No relationship between SRY variants and risk of Parkinson's disease in Chinese population

Hongxu Pan; Yige Wang; Yuwen Zhao; Li Jiang; Qian Zeng; Yan He; Zhenghuan Fang; Zheng Wang; Qian Xu; Qiying Sun; Jieqiong Tan; Xinxiang Yan; Jinchen Li; Beisha Tang; Jifeng Guo

doi:10.1016/j.neurobiolaging.2020.09.013

No relationship between SRY variants and risk of Parkinson's disease in Chinese population

Neurobiol Aging. 2021 Apr:100:119.e3-119.e6. doi: 10.1016/j.neurobiolaging.2020.09.013. Epub 2020 Sep 16.

Authors

Hongxu Pan¹, Yige Wang¹, Yuwen Zhao¹, Li Jiang¹, Qian Zeng¹, Yan He¹, Zhenghuan Fang², Zheng Wang³, Qian Xu⁴, Qiying Sun⁵, Jieqiong Tan⁶, Xinxiang Yan⁷, Jinchen Li⁸, Beisha Tang⁹, Jifeng Guo¹⁰

Affiliations

¹ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
² National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
³ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁴ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China.
⁵ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China; Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁶ Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
⁷ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁸ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China; Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁹ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China; Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
¹⁰ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China. Electronic address: [email protected].

PMID: 33041088
DOI: 10.1016/j.neurobiolaging.2020.09.013

Abstract

Parkinson's disease (PD) is a common neurodegenerative disease with inherent sex differences, and sex-determining region Y (SRY) is a gene located in the Y chromosome which encodes a transcription factor involving the regulation of the dopamine system. In this study, we investigated whether SRY variants were associated with PD in Chinese population. A total of 2058 male patients with PD and 1650 male control participants were recruited, and variants in SRY transcript and flanking regions were genotyped by whole-exome sequencing or whole-genome sequencing. Analysis of rare variants by the optimal sequence kernel association test showed no difference in variant burden of coding, 5'-noncoding and 3'-noncoding between the case and control group. In addition, of the 6 common variants identified, none showed a significant effect in altering PD risk in our population using logistic regression. Our results suggested SRY variants were not associated with the risk of PD in Chinese population.

Keywords: Chinese; Disease association; Parkinson's disease; SRY gene; Variants.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asian People / genetics
Chromosomes, Human, Y / genetics
Dopamine / metabolism
Exome Sequencing / methods
Genetic Association Studies / methods*
Genetic Variation / genetics*
Genotype
Genotyping Techniques
Humans
Logistic Models
Negative Results*
Parkinson Disease / genetics*
Risk
Sex-Determining Region Y Protein / genetics*
Transcription Factors / genetics
Transcription Factors / physiology

Substances

SRY protein, human
Sex-Determining Region Y Protein
Transcription Factors
Dopamine