Abstract
Autoantibodies reacting with bromelain-treated autologous mouse red blood cells (Br-MRBC) are spontaneously produced by normal mice. In order to understand the biological significance of these autoantibodies, anti-Br-MRBC monoclonal autoantibodies have been prepared and studied for reactivity with a panel of frozen tissue sections from organs of normal mice by direct immunofluorescence. It has been found that the anti-Br-MRBC monoclonal autoantibodies are polyspecific, since they react with cells in multiple organs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Monoclonal / immunology*
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Autoantibodies / immunology*
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Autoantigens / analysis*
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Autoantigens / immunology
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Bromelains / pharmacology
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Erythrocytes / drug effects
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Erythrocytes / immunology*
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Female
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Fluorescent Antibody Technique
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Gastric Mucosa / immunology
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Lymphoid Tissue / immunology
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Male
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Mice
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Mice, Inbred BALB C
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Salivary Glands / immunology
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Testis / immunology
Substances
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Antibodies, Monoclonal
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Autoantibodies
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Autoantigens
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Bromelains