Griffithsin with A Broad-Spectrum Antiviral Activity by Binding Glycans in Viral Glycoprotein Exhibits Strong Synergistic Effect in Combination with A Pan-Coronavirus Fusion Inhibitor Targeting SARS-CoV-2 Spike S2 Subunit

Virol Sin. 2020 Dec;35(6):857-860. doi: 10.1007/s12250-020-00305-3. Epub 2020 Oct 14.
No abstract available

Publication types

  • Letter

MeSH terms

  • Antiviral Agents / pharmacology*
  • Cell Line
  • Drug Repositioning
  • Drug Synergism
  • Humans
  • Inhibitory Concentration 50
  • Plant Lectins / pharmacology*
  • Polysaccharides / metabolism*
  • SARS-CoV-2 / drug effects*
  • Spike Glycoprotein, Coronavirus / metabolism*

Substances

  • Antiviral Agents
  • Plant Lectins
  • Polysaccharides
  • Spike Glycoprotein, Coronavirus
  • griffithsin protein, Griffithsia