Effect of Doxorubicin on Myocardial Bicarbonate Production From Pyruvate Dehydrogenase in Women With Breast Cancer

Circ Res. 2020 Dec 4;127(12):1568-1570. doi: 10.1161/CIRCRESAHA.120.317970. Epub 2020 Oct 14.

Jae Mo Park^{1

2

3}, Galen D Reed^{1

4}, Jeff Liticker¹, William C Putnam⁵, Alvin Chandra^{6

7}, Katarina Yaros⁸, Aneela Afzal^{1

6}, James MacNamara⁶, Jaffar Raza⁵, Ronald G Hall⁵, Jeannie Baxter¹, Kelley Derner¹, Salvador Pena¹, Raja Reddy Kallem⁵, Indhu Subramaniyan⁵, Vindhya Edpuganti⁵, Crystal E Harrison¹, Alagar Muthukumar⁹, Cheryl Lewis^{9

7}, Sangeetha Reddy^{9

7}, Nisha Unni^{10

7}, Dawn Klemow^{10

7}, Samira Syed^{10

7}, Hsiao Li^{10

7}, Suzanne Cole^{10

7}, Thomas Froehlich^{10

7}, Colby Ayers⁶, James de Lemos⁶, Craig R Malloy^{1

2

6

7

11}, Barbara Haley^{10

7}, Vlad G Zaha^{1

7}

¹ Advanced Imaging Research Center (J.M.P., G.D.R., J.L., A.A., J.B., K.D., S.P., C.E.H., C.R.M., V.G.Z.), University of Texas Southwestern Medical Center, Dallas.
² Radiology (J.M.P., C.R.M.), University of Texas Southwestern Medical Center, Dallas.
³ Electrical and Computer Engineering, The University of Texas at Dallas, Richardson (J.M.P.).
⁴ GE Healthcare, Dallas, TX (G.D.R.).
⁵ Pharmacy Practice, Jerry H. Hodge School of Pharmacy, Texas Tech University, Dallas Campus (W.C.P., J.R., R.G.H., R.R.K., I.S., V.E.).
⁶ Division of Cardiology (A.C., A.A., J.M., C.A., J.d.L., C.R.M.), University of Texas Southwestern Medical Center, Dallas.
⁷ Harold C. Simmons Comprehensive Cancer Center, Dallas, Texas (A.C., C.L., S.R., N.U., D.K., S.S., H.L., S.C., T.F., C.R.M., B.H., V.G.Z.).
⁸ Department of Internal Medicine (K.Y.), University of Texas Southwestern Medical Center, Dallas.
⁹ Pathology (A.M., C.L., S.R.), University of Texas Southwestern Medical Center, Dallas.
¹⁰ Division of Hematology and Oncology (N.U., D.K., S.S., H.L., S.C., T.F., B.H.), University of Texas Southwestern Medical Center, Dallas.
¹¹ Veterans Affairs North Texas Healthcare System, Dallas, Texas (C.R.M.).

No abstract available

Keywords: anthracyclines; carbon-13 magnetic resonance spectroscopy; cardiotoxicity; mitochondria, heart; pyruvate dehydrogenase complex.

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