Abstract
Richter syndrome or Richter transformation comprises the conversion of chronic lymphocytic leukemia into an aggressive type of large cell lymphoma. Classically, patients have diffuse and abrupt lymphadenopathy and organomegaly, in addition to fever, weight loss, and fatigue. Cutaneous involvement is rare and often nonspecific. We report a patient with chronic lymphocytic leukemia who presented with a large and rapidly evolving ulcer, revealed to be a high-grade cutaneous lymphoma.
MeSH terms
-
Aged
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
-
Cell Transformation, Neoplastic*
-
Cyclophosphamide / therapeutic use
-
Doxorubicin / therapeutic use
-
Female
-
Head and Neck Neoplasms / pathology*
-
Head and Neck Neoplasms / physiopathology
-
Head and Neck Neoplasms / therapy
-
Humans
-
Leukemia, Lymphocytic, Chronic, B-Cell / physiopathology*
-
Lymphoma, Large B-Cell, Diffuse / pathology*
-
Lymphoma, Large B-Cell, Diffuse / physiopathology
-
Lymphoma, Large B-Cell, Diffuse / therapy
-
Neck
-
Prednisone / therapeutic use
-
Radiotherapy
-
Rituximab / therapeutic use
-
Skin Neoplasms / pathology*
-
Skin Neoplasms / physiopathology
-
Skin Neoplasms / therapy
-
Skin Ulcer / pathology*
-
Surgical Procedures, Operative
-
Vincristine / therapeutic use
Substances
-
R-CHOP protocol
-
Rituximab
-
Vincristine
-
Doxorubicin
-
Cyclophosphamide
-
Prednisone